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The effect of ethanol extract from germinated Keunnunjami, blackish\u2010purple rice with a giant embryo, compare to ordinary brown rice, on the body weight and lipid and glucose metabolism in high\u2010fat diet\u2010fed mice was analyzed. Mice were fed with a high\u2010fat diet\u2010fed for 3 weeks and then orally administered with either distilled water (HF) or extract (0.25%, <jats:italic>w<\/jats:italic>\/<jats:italic>w<\/jats:italic>) from brown, germinated brown, Keunnunjami, and germinated Keunnunjami rice for 4 weeks. Control mice were fed with a normal diet and orally administered with distilled water. The HF group showed markedly higher body weight and triglyceride, cholesterol, fatty acid, glucose, and insulin levels than the control group. However, the oral administration of rice extracts ameliorated this high\u2010fat diet\u2010induced obesity, hyperlipidemia, and hypoglycemia through the modulation of adipokine production, lipogenic and glucose\u2010regulating enzyme activities, and mRNA expression of genes associated with lipid and glucose metabolism. The germinated Keunnunjami extract exhibited greater hypolipidemic, hypoglycemic, and body weight\u2010lowering effects than the other rice extracts. The results demonstrated that germination could further enhance the physiological properties of rice and that germinated Keunnunjami extract has a strong therapeutic potential against high\u2010fat diet\u2010induced obesity, hyperlipidemia, and hyperglycemia.<\/jats:p>","DOI":"10.1155\/2021\/8829778","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T18:20:09Z","timestamp":1610734809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral Administration of Germinated, Pigmented, Giant Embryo Rice (<i>Oryza sativa<\/i> L. cv. Keunnunjami) Extract Improves the Lipid and Glucose Metabolisms in High\u2010Fat Diet\u2010Fed Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-7191","authenticated-orcid":false,"given":"Soo Im","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-8650","authenticated-orcid":false,"given":"Mi Young","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"WHO Obesity and overweight 2020 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"e_1_2_9_2_2","unstructured":"WHO Raised cholesterol 2020 https:\/\/www.who.int\/data\/gho\/indicator-metadata-registry\/imr-details\/3236\/."},{"key":"e_1_2_9_3_2","unstructured":"WHO The top ten causes of death 2020 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death\/."},{"key":"e_1_2_9_4_2","unstructured":"WHO Diabetes 2020 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes\/."},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(04)00091-5"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-1981(00)00156-6"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.11.018"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2008.04.007"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13765-014-4095-z"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094298"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12892-013-0055-0"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12892-014-0068-3"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112733"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2010.529624"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.86"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2005.00039.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b05361"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.09.025"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf403703t"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.03.053"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2010.542259"},{"key":"e_1_2_9_22_2","first-page":"185","article-title":"A new rice variety \u2018Keunnunjami\u2019, with high concentrations of cyanidin 3-glucoside and giant embryo","volume":"44","author":"Han S. 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