{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:23:29Z","timestamp":1767925409837,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:p>Objectives. To investigate the relationship between the eccentric calcification of aortic valve and transcatheter heart valve (THV) distortion and the impact of THV distortion on echo parameters and clinical outcomes. Background. The effects of eccentric calcification of the aortic valve on the THV distortion and the relationship between THV distortion and clinical impact were not fully understood. Methods. Patients with symptomatic severe aortic stenosis who were undergoing THV implantation were enrolled. Patients underwent preprocedural, postprocedural multislice computed tomography (MSCT), and follow-up transthoracic echocardiogram (TTE). Delta calcium score (\u0394CS) is defined as the difference between the maximum and minimal calcium scores of the three cusps, while valve distortion score (VDS) is defined as the difference between the longest and shortest stent frame, as obtained using MSCT. Patients were divided into two groups according to \u0394CS: \u201cnoneccentric calcification group\u201d and \u201ceccentric calcification group.\u201d Results. A total of 118 patients were enrolled (59 patients in noneccentric and 59 in eccentric calcification groups). VDS was significantly lower in the noneccentric calcification group than in the eccentric calcification group (1.31\u2009\u00b1\u20090.82\u2009mm vs. 1.73\u2009\u00b1\u20090.76\u2009mm, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.004<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). VDS was not associated with the degree of paravalvular leak (PVL) and aortic valvular mean pressure gradient (AVPG) at 30-day and 1-year follow-up TTE and the cumulative rates of all-cause death and rehospitalization at 2-year clinical follow-up. Conclusions. Eccentric valvular calcification was associated with longitudinal THV distortion. However, THV distortion was not associated with PVL, AVPG, and adverse clinical events during midterm follow-up.<\/jats:p>","DOI":"10.1155\/2021\/8829906","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T02:12:28Z","timestamp":1609899148000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["The Impact of Aortic Valvular Calcium on Transcatheter Heart Valve Distortion"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-2586","authenticated-orcid":true,"given":"Akihiro","family":"Nakajima","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-1358","authenticated-orcid":true,"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhito","family":"Yuki","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Onishi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Amano","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Yabushita","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, New Tokyo Hospital, Chiba, 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