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However, during the period of LIPUS therapy, it is undetermined whether LIPUS promotes the formation of heterotopic ossification (HO), which usually occurs in muscle tissues after trauma such as bone fracture and spinal cord injury. Here, we used 6\u2010week LIPUS therapy in a 42\u2010year\u2010old Chinese male patient with a fracture nonunion in combination with ultrasonography for monitoring fracture healing and HO formation. After the LIPUS therapy, the mineralized bone formation in the area of defect of the distal tibia was presented in an ultrasound image, which was consistent with the outcome of plain radiography showing callus formation and the blurred fracture line in the area exposed to LIPUS. In addition, ultrasound images revealed no evidence of HO development within soft tissues during the period of LIPUS therapy. This study suggests that ultrasonography is a potential tool to guarantee the performance of LIPUS therapy with monitoring HO formation. Easy to use, the integration of the handheld ultrasound scanner and the ultrasonic therapeutic apparatus is entirely dedicated to help orthopedists make high\u2010quality care and diagnosis.<\/jats:p>","DOI":"10.1155\/2021\/8834795","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T02:20:13Z","timestamp":1611800413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fracture Nonunion Treated with Low\u2010Intensity Pulsed Ultrasound and Monitored with Ultrasonography: A Feasibility Study"],"prefix":"10.1155","volume":"2021","author":[{"given":"Peizhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengdong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihai","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wufan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-6090","authenticated-orcid":false,"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-266X","authenticated-orcid":false,"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-20-05-273"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2018.11.004"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-198702010-00004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2005.06.002"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2017.05.016"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200910000-00007"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199707000-00002"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199004030-00002"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.2.145"},{"key":"e_1_2_9_10_2","first-page":"590","article-title":"Low intensity pulsed ultrasound affects adenylate cyclase activity and TGF-\u03b2 synthesis in osteoblastic cells","volume":"7","author":"Ryaby J. 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