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In this study, we investigated the regulation of gelatinase\u2010B (MMP\u20109) by\n                    <jats:italic>S. cumini<\/jats:italic>\n                    methanol seed extract (MSE) in diabetic cardiomyopathy using real\u2010time PCR, RT\u2010PCR, immunocytochemistry, gel diffusion assay, and substrate zymography. The regulatory effects of MSE on NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and IL\u20106 were also examined. Identification and estimation of polyphenol constituents present in\n                    <jats:italic>S. cumini<\/jats:italic>\n                    extract were carried out using reverse\u2010phase HPLC. Further,\n                    <jats:italic>in silico<\/jats:italic>\n                    docking studies of identified polyphenols with gelatinase\u2010B were performed to elucidate molecular level interaction in the active site of gelatinase\u2010B. Docking studies showed strong interaction of\n                    <jats:italic>S. cumini<\/jats:italic>\n                    polyphenols with gelatinase\u2010B. Our findings indicate that MSE significantly suppresses gelatinase\u2010B expression and activity in high\u2010glucose\u2010 (HG\u2010) stimulated cardiomyopathy. Further, HG\u2010induced activation of NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and IL\u20106 was also remarkably reduced by MSE. Our results suggest that\n                    <jats:italic>S. cumini<\/jats:italic>\n                    MSE may be useful as an effective functional food and dietary supplement to regulate HG\u2010induced cardiac stress through gelatinase.\n                  <\/jats:p>","DOI":"10.1155\/2021\/8839479","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T17:35:08Z","timestamp":1614879308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Anti\u2010inflammatory Effects of\n                    <i>S. cumini<\/i>\n                    Seed Extract on Gelatinase\u2010B (MMP\u20109) Regulation against Hyperglycemic Cardiomyocyte Stress"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2683-9464","authenticated-orcid":false,"given":"Neha","family":"Atale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-5912","authenticated-orcid":false,"given":"Chandra Bhushan","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrey","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-1844","authenticated-orcid":false,"given":"Raj Kumar","family":"Mongre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-1654","authenticated-orcid":false,"given":"Amresh","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-234X","authenticated-orcid":false,"given":"Umesh C. 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