{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:18:56Z","timestamp":1790893136760,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Committee of Hunan Province","award":["20200901"],"award-info":[{"award-number":["20200901"]}]},{"name":"Health Committee of Hunan Province","award":["2020079"],"award-info":[{"award-number":["2020079"]}]},{"name":"Traditional Chinese Medicine Bureau of Hunan Province","award":["20200901"],"award-info":[{"award-number":["20200901"]}]},{"name":"Traditional Chinese Medicine Bureau of Hunan Province","award":["2020079"],"award-info":[{"award-number":["2020079"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Polygonatum sibiricum<\/jats:italic>\n                    , a well\u2010known life\u2010prolonging tonic in Chinese medicine, has been widely used for nourishing nerves in the orient, but the underlying molecular mechanisms remain unclear. In this study, we found that\n                    <jats:italic>P. sibiricum<\/jats:italic>\n                    polysaccharides (PSP) ameliorated 1\u2010methyl\u20104\u2010phenyl\u20101,2.3,6\u2010tetrahydropyridine\u2010 (MPTP\u2010) induced locomotor activity deficiency and dopaminergic neuronal loss in an\n                    <jats:italic>in vivo<\/jats:italic>\n                    Parkinson\u2019s disease (PD) mouse model. Additionally, PSP pretreatment inhibited\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u20104\u2010phenylpyridine (MPP+) induced the production of reactive oxygen species, increasing the ratio of reduced glutathione\/oxidized glutathione.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments showed that PSP promoted the proliferation of N2a cells in a dose\u2010dependent manner, while exhibiting effects against oxidative stress and neuronal apoptosis elicited by MPP+. These effects were found to be associated with the activation of Akt\/mTOR\u2010mediated p70S6K and 4E\u2010BP1 signaling pathways, as well as nuclear factor erythroid 2\u2010related factor 2\u2010 (Nrf2\u2010) mediated NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase\u20101 (HO\u20101), glutamate\u2010cysteine ligase catalytic subunit (Gclc), and glutamate\u2010cysteine ligase modulatory subunit (Gclm), resulting in antiapoptotic and antioxidative effects. Meanwhile, PSP exhibited no chronic toxicity in C57BJ\/6 mice. Together, our results suggest that PSP can serve as a promising therapeutic candidate with neuroprotective properties in preventing PD.\n                  <\/jats:p>","DOI":"10.1155\/2021\/8843899","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:50:12Z","timestamp":1610585412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["<i>Polygonatum sibiricum<\/i>\n                    Polysaccharides Protect against MPP\u2010Induced Neurotoxicity via the Akt\/mTOR and Nrf2 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