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Hepatoma-derived growth factor, a growth factor related to normal development, is associated with neurotransmitters surrounding neurons and glial cells. Therefore, the study aims to investigate how blocking hepatoma-derived growth factor affects the inflammatory response in neuropathic pain. Serum hepatoma-derived growth factor protein expression was measured via ELISA. Resiniferatoxin was administrated intraperitoneally to induce neuropathic pain in 36 male Sprague-Dawley rats which were divided into three groups (resiniferatoxin+recombinant hepatoma-derived growth factor antibody group, resiniferatoxin group, and control group) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>12<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>\/group). The mechanical threshold response was tested with calibration forceps. Cell apoptosis was measured by TUNEL assay. Immunofluorescence staining was performed to detect apoptosis of neuron cells and proliferation of astrocytes in the spinal cord dorsal horn. RT-PCR technique and western blot were used to measure detect inflammatory factors and protein expressions. Serum hepatoma-derived growth factor protein expression was higher in the patients with sciatica compared to controls. In resiniferatoxin-group rats, protein expression of hepatoma-derived growth factor was higher than controls. Blocking hepatoma-derived growth factor improved the mechanical threshold response in rats. In dorsal root ganglion, blocking hepatoma-derived growth factor inhibited inflammatory cytokines. In the spinal cord dorsal horn, blocking hepatoma-derived growth factor inhibited proliferation of astrocyte, apoptosis of neuron cells, and attenuated expressions of pain-associated proteins. The experiment showed that blocking hepatoma-derived growth factor can prevent neuropathic pain and may be a useful alternative to conventional analgesics.<\/jats:p>","DOI":"10.1155\/2021\/8854461","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T19:35:08Z","timestamp":1614540908000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Chieh-Hsin","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Kung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ching","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Pei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-4456","authenticated-orcid":true,"given":"Ying-Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Shu-Zen Junior College of Medicine and Management, Kaohsiung 821, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-2771","authenticated-orcid":true,"given":"Chih-Lung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.08.049"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00257-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0113"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181bef710"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.02.159"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22126"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02911.2003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e9f62f"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e3181630bb8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2018.04.008"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400089-MCP200"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200405150-00006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31509-0"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-14-2"},{"issue":"48","key":"15","first-page":"1639","article-title":"Antisense oligonucleotides of hepatoma-derived growth factor (HDGF) suppress the proliferation of hepatoma cells","volume":"49","author":"Y. 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