{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:31:17Z","timestamp":1788993077996,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A2B2006858"],"award-info":[{"award-number":["2017R1A2B2006858"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1I1A1A01064068"],"award-info":[{"award-number":["2019R1I1A1A01064068"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Gastroesophageal reflux disease (GERD) is induced by the reflux of stomach contents or gastric acid, pepsin into the esophagus for prolonged periods of time due to defection of the lower esophageal sphincter. Reflux esophagitis is a disease found in less than 50% of GERD patients. This study is aimed at evaluating the protective effect of Curcumae longae Rhizoma 30% EtOH extract (CLR) in acute reflux esophagitis (ARE) rats. CLR measured antioxidant activity through <jats:italic>in vitro<\/jats:italic> experiments. Based on the results, we performed experiments <jats:italic>in vivo<\/jats:italic>. Before 90\u2009min ARE induction, CLR was administered orally by concentration. ARE was derived by linking the metastatic junction between pylorus and forestomach and corpus in Sprague\u2010Dawley rats. And rats were sacrificed 5\u2009h after surgery. We analyzed the expression of antioxidant and inflammatory\u2010related markers by western blot and observed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), reactive oxygen species (ROS), peroxynitrite (ONOO<jats:sup>-<\/jats:sup>), and thiobarbituric acid reactive substance (TBARS). The administration of CLR reduced esophagus tissue damage in rats with acute reflux esophagitis and decreased the elevated ALT, AST, ROS, ONOO<jats:sup>-<\/jats:sup>, and TBARS. In addition, CLR effectively increased antioxidant\u2010related factors and reduced inflammatory protein. Overall, these results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE. Overall, CLR treatment informed that markedly ameliorated inactivation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B led to the inhibition of the expressions of proinflammatory proteins. These results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE.<\/jats:p>","DOI":"10.1155\/2021\/8854945","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T18:50:35Z","timestamp":1610995835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Jin A.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4365-6988","authenticated-orcid":false,"given":"Mi-Rae","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4283-0809","authenticated-orcid":false,"given":"Hae-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-6849","authenticated-orcid":false,"given":"Seong-Soo","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0332-2"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113622"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.12.004"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.14"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(18)30475-6"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00199-3"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.34"},{"key":"e_1_2_10_8_2","first-page":"25","article-title":"Antioxidative activity of flavonoids in stimulated human neutrophils","volume":"38","author":"Zielinska M.","year":"2000","journal-title":"Folia Histochemica et Cytobiologica"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000031"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.066"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i25.4644"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.3972"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0974-z"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100741"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077195"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.12.013"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061477"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2019.07.010"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1834681"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)88697-5"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740640204"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025020"},{"key":"e_1_2_10_25_2","first-page":"637","article-title":"Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity","volume":"13","author":"Ali S. 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