{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:53:41Z","timestamp":1747756421581,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2018R1C1B5083580"],"award-info":[{"award-number":["2018R1C1B5083580"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,3,10]]},"abstract":"<jats:p>Cudrania tricuspidata (C. tricuspidata) is widespread throughout East Asia and in China and Korea, and it is widely used as a traditional remedy against eczema, mumps, and tuberculosis. With regard to the aforementioned medical efficacy, various studies are continuously being conducted, and it has been reported that C. tricuspidata extract has various actions against inflammation, diabetes, obesity, and tumors. Therefore, we evaluated antiplatelet effects using derrone in C. tricuspidata. We examined the effect of derrone on the phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and inositol 1, 4, 5-triphosphate receptor I (IP3RI), and on the dephosphorylation of cytosolic phospholipase A2 (cPLA2), mitogen-activated protein kinases p38 (p38MAPK), and Akt, which affects platelet function and thrombus formation. Various agonists-induced human platelets were inhibited by derrone without cytotoxicity, and it also decreased the intracellular calcium level through the signaling molecule phosphorylations. In addition, derrone inhibited glycoprotein IIb\/IIIa (\u03b1IIb\/\u03b23) affinity. Thus, in the present study, derrone suppressed human platelet aggregation and thrombin-induced clot formation.<\/jats:p>","DOI":"10.1155\/2021\/8855980","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T20:20:08Z","timestamp":1615494008000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Derrone Inhibits Platelet Aggregation, Granule Secretion, Thromboxane A2 Generation, and Clot Retraction: An In Vitro Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-3694","authenticated-orcid":true,"given":"Jung-Hae","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung 25601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-8231","authenticated-orcid":true,"given":"Muhammad","family":"Irfan","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Department of Oral Biology, University of Illinois at Chicago, Chicago 60607, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-1318","authenticated-orcid":true,"given":"Man Hee","family":"Rhee","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-2814","authenticated-orcid":true,"given":"Hyuk-Woo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, Far East University, Eumseong 27601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000366"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.07.020"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.11.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2515"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7656919"},{"key":"6","article-title":"Is traditional Chinese Medicine, \u201cRadix ilicis pubescentis\u201d possible for treating cardiovascular disease?","volume":"5","author":"S. Law","year":"2020","journal-title":"Traditional and Integrative Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2018.1431210"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2019.05.005"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04576.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.6.1245"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/09537100310001598819"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(01)00760-2"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5545"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(92)90675-b"},{"key":"15","first-page":"298","article-title":"Cudrania Tricuspidata root extract (CTE) has an anti-platelet effect via cGMP-dependent VASP phosphorylation in human platelets","volume":"20","author":"J. Y. Ro","year":"2019","journal-title":"Journal of the Korea Academia-Industrial Cooperation Society"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3839\/jabc.2019.014"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/2151027a0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(19)83641-4"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.15616\/bsl.2018.24.3.253"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90699-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m009218200"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1039\/c7ra04322h"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0290-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90666-e"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03169.x"},{"key":"26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.20307\/nps.2020.26.4.295","article-title":"Antiplatelet effect of cudraxanthone L isolated from Cudrania tricuspidata via inhibition of phosphoproteins","volume":"26","author":"J. 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