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Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.<\/jats:p>","DOI":"10.1155\/2021\/8856649","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:05:12Z","timestamp":1615248312000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-3677","authenticated-orcid":true,"given":"Jiankun","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre F.","family":"Saldinger","sequence":"additional","affiliation":[{"name":"Department of Surgery, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA"},{"name":"Weill Cornell Medical College, 525 East 68th Street, Box 130, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA"},{"name":"Weill Cornell Medical College, 525 East 68th Street, Box 130, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1111\/j.1365-2141.1989.tb00251.x"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1002\/path.1711600105"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.3960\/jslrt.53.1"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"6","first-page":"468","volume-title":"WHO Classification of Tumor of Haematopoietic and Lymphoid Tissue","author":"S. 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