{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:53:04Z","timestamp":1781232784473,"version":"3.54.1"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015375","name":"Affiliated Hospital of Southwest Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>. Portal vein thrombosis is a serious adverse event that occurs during liver cirrhosis. We performed a meta\u2010analysis to evaluate the safety and efficacy of anticoagulant therapy and prophylactic anticoagulant therapy in cirrhosis patients with (\/without) portal vein thrombosis. <jats:italic>Methods<\/jats:italic>. Eligible comparative studies were identified by searching the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. A meta\u2010analysis was performed to calculate odds ratios and 95% confidence intervals using fixed\u2010effects models. Recanalization and thrombus progression were defined as the primary outcomes. Secondary outcomes included adverse events and death mortality. <jats:italic>Results<\/jats:italic>. A total of 3479 patients were included in this analysis. Compared with the control group, the recanalization rate in the anticoagulant therapy group was increased (<jats:italic>P<\/jats:italic> &lt; 0.00001) in patients with cirrhosis and portal vein thrombosis without increasing adverse events. Multiple use of enoxaparin in small doses is safer than single large doses (<jats:italic>P<\/jats:italic> = 0.004). Direct oral anticoagulants are more effective (<jats:italic>P<\/jats:italic> &lt; 0.00001) and safer than traditional anticoagulants. Prophylactic anticoagulant therapy can effectively prevent portal vein thrombosis formation (<jats:italic>P<\/jats:italic> &lt; 0.00001). <jats:italic>Conclusions<\/jats:italic>. Anticoagulation therapy can treat or prevent portal vein thrombosis in patients with liver cirrhosis and is a relatively safe treatment.<\/jats:p>","DOI":"10.1155\/2021\/8859602","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T14:05:23Z","timestamp":1619705123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and Efficacy of Anticoagulation in Patients with Cirrhosis: A 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