{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:16:17Z","timestamp":1774689377553,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Surgery"],"published-print":{"date-parts":[[2021,6,11]]},"abstract":"<jats:p>We report a rare case of a large Brunner\u2019s gland hyperplasia (BGH) with severe anemia. A 33-year-old woman was transferred to our hospital with anemia and a duodenal mass. She had a 2-week history of melena and mild shortness of breath. Her hemoglobin level was 4.9\u2009g\/dl, and she required a blood transfusion. Abdominal computed tomography revealed a 7\u2009cm tumor in the descending duodenum, and duodenoscopy revealed a polyp-like tumor with an ulcer at the duodenal bulb. We decided to perform surgery to prevent further bleeding. Intraoperatively, the tumor stalk was located at the anterior wall of the duodenal bulb; the ampulla was not involved, and we resected the tumor with the wall of the duodenal bulb. The resected tumor measured <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>7.0<\/a:mn>\n                        <a:mo>\u00d7<\/a:mo>\n                        <a:mn>4.0<\/a:mn>\n                        <a:mo>\u00d7<\/a:mo>\n                        <a:mn>2.3<\/a:mn>\n                        <a:mtext>\u2009<\/a:mtext>\n                        <a:mtext>cm<\/a:mtext>\n                     <\/a:math>\n                  <\/jats:inline-formula>, and pathologically, the tumor consisted of proliferated Brunner\u2019s glands in a small amount of fibrous stroma. The histological diagnosis was BGH with no malignancy. Most cases of BGH are benign and asymptomatic; however, it is important to be aware that some patients have severe anemia, gastrointestinal obstruction, or malignant potential.<\/jats:p>","DOI":"10.1155\/2021\/8861308","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T18:35:06Z","timestamp":1623522906000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Large Brunner\u2019s Gland Hyperplasia with Bleeding: A Case Report"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yuki","family":"Okutomi","sequence":"first","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-1654","authenticated-orcid":true,"given":"Takaharu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toishiki","family":"Rikiyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","first-page":"7565","article-title":"Brunner's gland adenoma of duodenum: report of two cases","volume":"8","author":"L. Lu","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-018-0856-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-015-0425-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/2011.5.2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6940649"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9623"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1159\/000111076"},{"issue":"11","key":"8","first-page":"1256","article-title":"The pathological expressions of Brunners gland hyperplasia into adenoma and hamartoma","volume":"24","author":"F. A. Al-Hilli","year":"2003","journal-title":"Saudi Medical Journal"}],"container-title":["Case Reports in Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2021\/8861308.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2021\/8861308.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cris\/2021\/8861308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T18:35:09Z","timestamp":1623522909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cris\/2021\/8861308\/"}},"subtitle":[],"editor":[{"given":"Neil Donald","family":"Merrett","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":8,"alternative-id":["8861308","8861308"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8861308","relation":{},"ISSN":["2090-6919","2090-6900"],"issn-type":[{"value":"2090-6919","type":"electronic"},{"value":"2090-6900","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,11]]}}}