{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:56:14Z","timestamp":1787496974412,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Municipal Administration of Hospitals\u2019 Mission Plan","award":["SML20150501"],"award-info":[{"award-number":["SML20150501"]}]},{"name":"Beijing Municipal Administration of Hospitals\u2019 Mission Plan","award":["D161100003816005"],"award-info":[{"award-number":["D161100003816005"]}]},{"name":"Beijing Municipal Administration of Hospitals\u2019 Mission Plan","award":["2016YFC1301800"],"award-info":[{"award-number":["2016YFC1301800"]}]},{"name":"Beijing Science and Technology Supporting Plan","award":["SML20150501"],"award-info":[{"award-number":["SML20150501"]}]},{"name":"Beijing Science and Technology Supporting Plan","award":["D161100003816005"],"award-info":[{"award-number":["D161100003816005"]}]},{"name":"Beijing Science and Technology Supporting Plan","award":["2016YFC1301800"],"award-info":[{"award-number":["2016YFC1301800"]}]},{"name":"National Key Technologies Research and Development Program of China","award":["SML20150501"],"award-info":[{"award-number":["SML20150501"]}]},{"name":"National Key Technologies Research and Development Program of China","award":["D161100003816005"],"award-info":[{"award-number":["D161100003816005"]}]},{"name":"National Key Technologies Research and Development Program of China","award":["2016YFC1301800"],"award-info":[{"award-number":["2016YFC1301800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,3,30]]},"abstract":"<jats:p>\n                    Objective. We aimed to investigate the risk factors associated with hemorrhage and clarify the relation of homocysteine (Hcy) with brain arteriovenous malformations (bAVMs). Method. We retrospectively reviewed bAVM patients from Beijing Tiantan Hospital between January 2019 and December 2019. Clinical and laboratory variables were analyzed in enrolled patients with bAVMs. Potential predictors associated with hemorrhage were evaluated by logistic regression analysis. Results. A total of 143 bAVM patients were identified in the study, including 69 unruptured and 74 ruptured cases. Patients with hemorrhage were less likely to have hyperhomocysteinemia (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.023<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Logistic regression analysis showed that increased maximum diameter of bAVM lesions (odds ratio (OR) 0.634, 95% confidence intervals (CI) 0.479-0.839;\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) and serum Hcy level (OR 0.956, 95% CI 0.920-0.993;\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.021<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ) were associated with lower risk of hemorrhage in bAVMs. Conclusion. The present study provided evidence regarding the association between serum Hcy and hemorrhage in patients with bAVMs. Higher Hcy level was correlated with a lower risk of rupture. Detection of factors for subsequent hemorrhage is necessary to develop therapeutic strategies for bAVMs preferably.\n                  <\/jats:p>","DOI":"10.1155\/2021\/8862299","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T16:08:58Z","timestamp":1617206938000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Homocysteine Level and Risk of Hemorrhage in Brain Arteriovenous Malformations"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-0256","authenticated-orcid":true,"given":"Chaofan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-2652","authenticated-orcid":true,"given":"Fa","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peicong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-4971","authenticated-orcid":true,"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-5390","authenticated-orcid":true,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-0255","authenticated-orcid":true,"given":"Jizong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"},{"name":"Savaid Medical School, University of the Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp067192"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709449"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000688"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/1971400918759811"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60872-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/783721"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102019"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02401-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.02.076"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0634-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.10.022"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.11.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.1"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s007260170009"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000086753.00555.0d"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000131942.77635.2d"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21019-3"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000009093"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.05.011"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000169934.96354.3a"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.21.2644"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000720"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-019-01138-9"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-018-0268-5"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2297-0"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.066"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00376.2005"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21757"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0116-z"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000061888.71524.DF"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.064"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.10.026"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200606000-00002"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.558403"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(10)60053-8"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.4.0476"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.6.0918"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.02.050"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/8862299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/8862299.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/8862299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T16:09:05Z","timestamp":1617206945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2021\/8862299\/"}},"subtitle":[],"editor":[{"given":"Wen-Jun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":40,"alternative-id":["8862299","8862299"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8862299","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,30]]}}}