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Herein, we try to dissect the pharmacology of methanol extracts (MEs) of velvet antler on Parkinson\u2019s disease (PD). <jats:italic>Caenorhabditis elegans<\/jats:italic> studies showed that MEs decreased the aggregation of <jats:italic>\u03b1<\/jats:italic>\u2010synuclein and protected oxidative stress\u2010induced DAergic neuron degeneration. <jats:italic>In vitro<\/jats:italic> cellular data indicated that MEs suppressed the LPS\u2010induced MAPKs and NF\u2010<jats:italic>\u03ba<\/jats:italic>B activation, therefore inhibiting overproduction of reactive oxygen species, nitric oxide, tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>, and interleukin\u20106; blocking microglia activation; and protecting DAergic neurons from the microglia\u2010mediated neurotoxicity. <jats:italic>In vivo<\/jats:italic> MPTP\u2010induced PD mouse investigations found that MEs prevented MPTP\u2010induced neuron loss in the substantia nigra and improved the behavioral rotating rod performance in MPTP\u2010treated mice by increasing the expression level of tyrosine hydroxylase (TH) and downregulating <jats:italic>\u03b1<\/jats:italic>\u2010synuclein protein expression. In all, these results demonstrate that MEs ameliorate PD by inhibiting oxidative stress and neuroinflammation.<\/jats:p>","DOI":"10.1155\/2021\/8864395","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T02:56:50Z","timestamp":1610247410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Velvet Antler Methanol Extracts Ameliorate Parkinson\u2019s Disease by Inhibiting Oxidative Stress and Neuroinflammation: From <i>C. elegans<\/i> to 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