{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:26:22Z","timestamp":1772303182785,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Science and Technology Program of Shantou City in China","award":["Project 200619185260626"],"award-info":[{"award-number":["Project 200619185260626"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:p>Background. More than 40% of patients with cancer have reported that chemotherapy-induced nausea and vomiting (CINV) remained the most debilitating side effects of treatment even in the era of new antiemetics. Objective. The purpose of this review was to systematically evaluate the clinical effect of auricular acupressure (AA) in prevention and treatment of chemotherapy-induced nausea and vomiting. Methods. The following databases were searched: PubMed, Cochrane Library, EMBASE, the Web of Science, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, and VIP (from database inception to April 2020). Eligible randomized controlled trials of auricular acupressure in treating CINV were collected, including crossover randomized design study. The meta-analysis was carried out by RevMan software (5.3). Results. Totally 19 RCTs with 1449 patients met the inclusion criteria. Compared with control groups, the relief efficiency of overall CINV was enhanced by AA combined with antiemetics (RR\u2009=\u20091.31, CI 1.22 to 1.41, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009\u2264\u20090.001). Although the therapeutic effect on acute nausea and vomiting was not obvious, AA still played an important role in reducing delayed nausea and vomiting (delayed nausea frequency: RR\u2009=\u20090.68, CI \u22121.01 to \u22121.35, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009\u2264\u20090.001; delayed vomiting frequency: RR\u2009=\u20090.91, CI \u22121.22 to \u22120.61, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009\u2264\u20090.001). The likelihood of adverse reactions related to antiemetics was reduced by AA combined with antiemetics (RR\u2009=\u20090.62, CI 0.53 to 0.74, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009\u2264\u20090.001). Statistically significant association was found between AA and incidence of constipation, diarrhea, and tiredness, while there was no statistically significant association between AA and abdominal distension or headache. Conclusion. Auricular acupressure supplementation benefited delayed chemotherapy-induced nausea and vomiting as well as constipation, diarrhea, and tiredness. AA alone or AA supplementation has little effect on acute nausea and acute vomiting. There is no conclusion on whether AA alone is superior to antiemetics in the management of delayed CINV. Further studies are needed to confirm the efficacy of auricular acupressure alone in delayed CINV and anticipatory CINV. The results of this review provided the basis for further research with more rigorous study designs, adequate sample sizes, and standardized implementation to confirm the efficacy of auricular acupressure.<\/jats:p>","DOI":"10.1155\/2021\/8868720","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T21:50:08Z","timestamp":1628113808000},"page":"1-11","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Auricular Acupressure in Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting in Patients with Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-4558","authenticated-orcid":true,"given":"Lichan","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College, Shantou, China"},{"name":"Shantou University Medical College, Shantou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-6116","authenticated-orcid":true,"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shantou University Medical College, Shantou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-1930","authenticated-orcid":true,"given":"Xisui","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College, Shantou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7714-4307","authenticated-orcid":true,"given":"Chunjiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4131-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02480.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/01635580903305276"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.05.001"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1515442"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.001"},{"issue":"11","key":"7","first-page":"16","article-title":"Chinese expert consensus on the prevention and treatment of nausea and vomiting associated with tumor drug therapy (2019 edition)","volume":"11","author":"W. 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H. Liu","year":"2011","journal-title":"Modern Journal Of Integrated Traditional Chinese and Western Medicine"},{"key":"20","unstructured":"LouL.The ears pressure bean treatment platinum-based regime chemotherapy induced nausea and vomiting clinical research2011Guangzhou, ChinaGuangzhou University of Chinese MedicineMaster Thesis"},{"issue":"4","key":"21","first-page":"52","article-title":"Clinical observation on ear pressure treatment of 43 cases of chemotherapy-related vomiting","volume":"44","author":"X. Q. Jiang","year":"2012","journal-title":"Jiangsu Journal of Traditional Chinese Medicine"},{"issue":"6","key":"22","first-page":"516","article-title":"Therapeutic observation of auricular point sticking for vomiting due to chemotherapy for mammary cancer","volume":"33","author":"R. 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