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TLR4 is an innate immune receptor on the cell surface that recognizes pathogen\u2010associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammatory cytokines to combat infection. It is expressed on both immune cells and tissue\u2010resident cells. ACE2, the reported entry receptor for SARS\u2010CoV\u20102, is only present on ~1\u20102% of the cells in the lungs or has a low pulmonary expression, and recently, the spike protein has been proposed to have the strongest protein\u2010protein interaction with TLR4. Here, we review and connect evidence for SARS\u2010CoV\u20101 and SARS\u2010CoV\u20102 having direct and indirect binding to TLR4, together with other viral precedents, which when combined shed light on the COVID\u201019 pathophysiological puzzle. We propose a model in which the SARS\u2010CoV\u20102 spike glycoprotein binds TLR4 and activates TLR4 signalling to increase cell surface expression of ACE2 facilitating entry. SARS\u2010CoV\u20102 also destroys the type II alveolar cells that secrete pulmonary surfactants, which normally decrease the air\/tissue surface tension and block TLR4 in the lungs thus promoting ARDS and inflammation. Furthermore, SARS\u2010CoV\u20102\u2010induced myocarditis and multiple\u2010organ injury may be due to TLR4 activation, aberrant TLR4 signalling, and hyperinflammation in COVID\u201019 patients. Therefore, TLR4 contributes significantly to the pathogenesis of SARS\u2010CoV\u20102, and its overactivation causes a prolonged or excessive innate immune response. TLR4 appears to be a promising therapeutic target in COVID\u201019, and since TLR4 antagonists have been previously trialled in sepsis and in other antiviral contexts, we propose the clinical trial testing of TLR4 antagonists in the treatment of severe COVID\u201019. Also, ongoing clinical trials of pulmonary surfactants in COVID\u201019 hold promise since they also block TLR4.<\/jats:p>","DOI":"10.1155\/2021\/8874339","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T21:35:06Z","timestamp":1610746506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":322,"title":["COVID\u201019 and Toll\u2010Like Receptor 4 (TLR4): SARS\u2010CoV\u20102 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-5220","authenticated-orcid":false,"given":"Mohamed M.","family":"Aboudounya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-2362","authenticated-orcid":false,"given":"Richard 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