{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:20:48Z","timestamp":1780442448141,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2021,2,2]]},"abstract":"<jats:p>While the postoperative outcome is favorable, post-thyroidectomy pain is considerable. Reducing the postoperative acute pain, therefore, is considered important. This study investigated whether the pain intensity and need for rescue analgesics during the immediate postoperative period after thyroidectomy differ according to the methods of anesthesia. Seventy-two patients undergoing total thyroidectomy under general anesthesia were examined. Patients were randomly assigned to undergo either total intravenous anesthesia with remifentanil and propofol (TIVA, n\u2009=\u200935) or propofol induction and maintenance with desflurane and nitrous oxide (volatile anesthesia [VA], n\u2009=\u200937). The mean administered dose of remifentanil was 1977.7\u2009\u00b1\u2009722.5\u2009\u03bcg in the TIVA group, which was approximately 0.268\u2009\u00b1\u20090.118\u2009\u03bcg\/min\/kg during surgery. Pain scores based on a numeric rating scale (NRS) and the need for rescue analgesics were compared between groups at the postoperative anesthetic care unit (PACU). The immediate postoperative NRS values of the TIVA and VA groups were 5.7\u2009\u00b1\u20091.7 and 4.7\u2009\u00b1\u20092.3, respectively (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><\/a:math><\/jats:inline-formula>\u2009=\u20090.034). Postoperative morphine equianalgesic doses in the PACU were higher in the TIVA group than in the VA group (16.7\u2009\u00b1\u20093.8\u2009mg vs. 14.1\u2009\u00b1\u20095.9\u2009mg,<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><\/c:math><\/jats:inline-formula>\u2009=\u20090.027). The incidence of immediate postanesthetic complications did not differ significantly between groups. In conclusion, more rescue analgesics were required in the TIVA group than in the VA group to adequately manage postoperative pain while staying in the PACU after thyroidectomy.<\/jats:p>","DOI":"10.1155\/2021\/8876906","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T19:55:34Z","timestamp":1612295734000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5387-6474","authenticated-orcid":true,"given":"Jun-Young","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-0235","authenticated-orcid":true,"given":"Seong-Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-3616","authenticated-orcid":true,"given":"Kyung-Don","family":"Hahm","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcome Research, Asan Medical Centre, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/hed.21757","article-title":"Outcomes after thyroidectomy and parathyroidectomy","volume":"34","author":"P. 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Dieudonne","year":"2001","journal-title":"Anesthesia & Analgesia"},{"key":"5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jss.2019.03.050","article-title":"A review of postoperative pain management for thyroid and parathyroid surgery","volume":"241","author":"R. A. Uhlmann","year":"2019","journal-title":"Journal of Surgical Research"},{"issue":"7","key":"6","article-title":"Differential postoperative effects of volatile anesthesia and intraoperative remifentanil infusion in 7511 thyroidectomy patients: a propensity score matching analysis","volume":"95","author":"J.-Y. Jo","year":"2016","journal-title":"Medicine"},{"key":"7","article-title":"Total intravenous anesthesia (TIVA) with propofol for acute postoperative pain: a scoping review of randomized controlled trials","volume":"95","author":"S. S. C. 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