{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:43:31Z","timestamp":1789245811220,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2021,2,2]]},"abstract":"<jats:p>Background. The World Health Organization estimated that about 1.36 million pregnant women suffered from syphilis in 2008, and nearly 66% of adverse effects occurred in those who were not tested or treated. Syphilis infection is one of the most common maternal factors associated with stillbirth. Objective. This study aimed to determine the risk factors for stillbirth among pregnant women infected with syphilis. Methods. In this retrospective study, data on stillbirth and gestational syphilis from 2010 to 2016 were extracted from the prevention of mother-to-child transmission (PMTCT) program database in the Zhejiang province. A total of 8,724 pregnant women infected with syphilis were included. Multiple logistic regression analysis was performed to determine the degree of association between gestational syphilis and stillbirth. Results. We found that the stillbirth percentage among pregnant women infected with syphilis was 1.7% (152\/8,724). Compared with live births, stillbirth was significantly associated with lower maternal age, not being married, lower gravidity, the history of syphilis, nonlatent syphilis stage, higher maternal serum titer for syphilis, inadequate treatment for syphilis, and later first antenatal care visit. In multiple logistic analysis, nonlatent syphilis (adjusted odds ratio (AOR)\u2009=\u20092.03; 95% CI\u2009=\u20091.17, 3.53) and maternal titers over 1\u2009:\u20094 (AOR\u2009=\u20091.78; 95% CI\u2009=\u20091.25, 2.53) were risk factors for stillbirth, and adequate treatment was the only protective factor for stillbirth (AOR\u2009=\u20090.16; 95% CI\u2009=\u20090.10, 0.25). Conclusions. Nonlatent syphilis and maternal titers over 1\u2009:\u20094 were risk factors for stillbirth, and adequate treatment was the only protective factor for stillbirth.<\/jats:p>","DOI":"10.1155\/2021\/8877962","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T01:50:35Z","timestamp":1612317035000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Risk Factors for Stillbirth among Pregnant Women Infected with Syphilis in the Zhejiang Province of China, 2010\u20132016"],"prefix":"10.1155","volume":"2021","author":[{"given":"Cui-Cui","family":"Duan","sequence":"first","affiliation":[{"name":"Women\u2019s Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Qian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-3198","authenticated-orcid":true,"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Zhejiang University School of Medicine, Hangzhou, China"},{"name":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"10053","key":"1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0140-6736(16)31575-6","article-title":"Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"GBD 2015 Child Mortality Collaborators","year":"2016","journal-title":"The Lancet"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37606"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.srhc.2016.12.002"},{"issue":"18","key":"4","article-title":"Understanding stillbirth stigma: a scoping literature review","volume":"S1871-5192","author":"D. Pollock","year":"2019","journal-title":"Women Birth"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14765"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)02010-0"},{"key":"7","volume-title":"The Global Elimination of Congenital Syphilis: Rationale and Strategy for Action","author":"World Health Organization, Department of Reproductive Health and Research","year":"2007"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1412-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(16)30135-8"},{"issue":"216","key":"10","first-page":"352","article-title":"Syphilis during pregnancy: a preventable threat to maternal-fetal health","volume":"4","author":"M. W. Rac","year":"2016","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002329"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052363"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0868-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/olq.0000000000000291"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(15)00271-5"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30461-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9194805"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.02.019"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12995"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-2014-8"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/qco.0000000000000270"},{"issue":"6","key":"22","first-page":"422","article-title":"Gestational syphilis and stillbirth in the Americas: a systematic review and meta-analysis","volume":"37","author":"L. Arnesen","year":"2015","journal-title":"Revista panamericana de salud publica Pan American journal of public health"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.09.017"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102203"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu920"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3896-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23562"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002363"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2017.1303379"},{"key":"30","article-title":"A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis","volume":"93","author":"H. D. Gliddon","year":"2016","journal-title":"Sexually Transmitted Infections"},{"issue":"21","key":"31","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1001\/jama.2016.5824","article-title":"Screening for syphilis infection in nonpregnant adults and adolescents: US preventive services task force recommendation statement","volume":"315","author":"K. Bibbins-Domingo","year":"2016","journal-title":"JAMA"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2021\/8877962.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2021\/8877962.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2021\/8877962.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T01:50:40Z","timestamp":1612317040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjidmm\/2021\/8877962\/"}},"subtitle":[],"editor":[{"given":"Christian","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":31,"alternative-id":["8877962","8877962"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8877962","relation":{},"ISSN":["1918-1493","1712-9532"],"issn-type":[{"value":"1918-1493","type":"electronic"},{"value":"1712-9532","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,2]]}}}