{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:06:57Z","timestamp":1788278817215,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p>Objective. To describe a case of lung cancer with brain metastasis in a patient who developed new late-onset bipolar disorder 2 years previously. Background. The typical onset age of bipolar disorder is approximately 20, and the first episode is usually a depressive episode. It is still not clear which age-specific factors contribute to the underlying risk. Materials and Methods. A 65-year-old male patient presented with a new-onset manic episode characterized by labile mood, impulsivity, decreased need for sleep, and grandiosity. He was diagnosed with late-onset bipolar disorder after excluding other possible physiological conditions. He was hospitalized in the acute psychiatric ward, and a combination of mood stabilizers and antipsychotics was prescribed. His mental condition improved, and he remained stable for 2 years. However, he experienced abrupt cognitive decline for 2 months and was referred to the emergency room for physiological examination. Results. The patient was diagnosed with lung cancer with brain metastasis by brain magnetic resonance imaging and whole-body positron emission tomography. Conclusion. In geriatric patients, who are at high risk of multiple medical conditions, excluding secondary causes of bipolar disorder is important.<\/jats:p>","DOI":"10.1155\/2021\/8880539","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T01:05:08Z","timestamp":1617411908000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Lung Cancer with Brain Metastasis following Late-Onset Bipolar Disorder"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-9982","authenticated-orcid":true,"given":"Shin-Heng","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, 333 Taoyuan, Taiwan"},{"name":"School of Medicine, Chang Gung University, 333 Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-1118","authenticated-orcid":true,"given":"Shwu-Hua","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, 333 Taoyuan, Taiwan"},{"name":"School of Medicine, Chang Gung University, 333 Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1906193"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12331"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00139.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2017.10.008"},{"key":"5","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","edition":"5th"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3242"},{"issue":"4","key":"7","first-page":"217","article-title":"Mania in an elderly subject: I. -- manic-depressive disorders of late onset","volume":"154","author":"V. 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