{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:52:37Z","timestamp":1773895957691,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871576"],"award-info":[{"award-number":["81871576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701901"],"award-info":[{"award-number":["81701901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2021,2,10]]},"abstract":"<jats:p>Keloids are scars characterized by abnormal proliferation of fibroblasts and overproduction of extracellular matrix components including collagen. We previously showed that LY2109761, a transforming growth factor- (TGF-) \u03b2 receptor inhibitor, suppressed the secretion of matrix components and slowed the proliferation of fibroblasts derived from human hypertrophic scar tissue. However, the exact mechanism underlying this effect remains unclear. Here, we replicated the above results in keloid-derived fibroblasts and show that LY2109761 promoted apoptosis, decreased the phosphorylation of Smad2 and Smad3, and suppressed TGF-\u03b21. These results suggest that the development and pathogenesis of keloids are positively regulated by the Smad2\/3 signaling pathway and the upregulation of TGF-\u03b21 receptors. LY2109761 and other inhibitors of these processes may therefore serve as therapeutic targets to limit excessive scarring after injury.<\/jats:p>","DOI":"10.1155\/2021\/8883427","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T11:54:53Z","timestamp":1613044493000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Inhibitory Effect of the LY2109761 on the Development of Human Keloid Fibroblasts"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-8298","authenticated-orcid":true,"given":"Xiuxia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Burns, Second Affiliated Hospital of Shandong First Medical University, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-8504","authenticated-orcid":true,"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-731X","authenticated-orcid":true,"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000819"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12346"},{"issue":"6","key":"3","first-page":"1358","article-title":"Peroxisome proliferator-activated receptor-\u03b3 agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression","volume":"6","author":"H. 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