{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:33Z","timestamp":1790957853916,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5\u2010methoxytryptophol (5\u2010MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters. <jats:italic>Methods<\/jats:italic>. This research was done using 32 male and female Wistar albino rats with weight between 200 and 250\u2009g. The rats were randomly divided into four groups: a control group (rats without any treatment), acute pulpitis (AP) group, AP+melatonin group, and AP+5\u2010MTX group. In the AP\u2010induced groups, the crowns of the upper left incisors were removed horizontally. Lipopolysaccharide solution was applied to the exposed pulp tissue before the canal orifices were sealed with a temporary filling material. Melatonin (10\u2009mg\/kg) and 5\u2010MTX (5\u2009mg\/kg) were administered intraperitoneally. The rats were sacrificed 24 hours after pulp injury, and trunk blood and pulp samples were collected. The concentrations of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, MMP\u20101, and MMP\u20102 in sera and pulp samples were determined using ELISA assay kits. <jats:italic>Results<\/jats:italic>. TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, MMP\u20101, and MMP\u20102 levels in the serum and pulp tissues were considerably higher in the AP group than the control group (<jats:italic>p<\/jats:italic> &lt; 0.01\u20100.001). In the AP+melatonin and AP+5\u2010MTX groups, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, MMP\u20101, and MMP\u20102 levels in the serum and pulp tissues were significantly lower than in the AP group (<jats:italic>p<\/jats:italic> &lt; 0.05\u20100.001). <jats:italic>Conclusions<\/jats:italic>. Both melatonin and 5\u2010MTX provided protective effects on acute pulpitis, which indicates they may be promising as a therapeutic strategy for oral disease.<\/jats:p>","DOI":"10.1155\/2021\/8884041","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T04:48:33Z","timestamp":1613278113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Anti\u2010Inflammatory Effects of Melatonin and 5\u2010Methoxytryptophol on Lipopolysaccharide\u2010Induced Acute Pulpitis in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-5312","authenticated-orcid":false,"given":"Fatma","family":"Kermeo\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-508X","authenticated-orcid":false,"given":"Umut","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-8751","authenticated-orcid":false,"given":"Abdullah","family":"Sebai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-6603","authenticated-orcid":false,"given":"G\u00f6k\u00e7e","family":"Savtekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-4085","authenticated-orcid":false,"given":"Hanife","family":"\u00d6zkayalar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-5369","authenticated-orcid":false,"given":"Serkan","family":"Say\u0131ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-9290","authenticated-orcid":false,"given":"Ahmet \u00d6zer","family":"\u015eehirli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"427","article-title":"Pulp-dentin biology in restorative dentistry. 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