{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:44:30Z","timestamp":1792856670481,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","award":["2017-A019-0215"],"award-info":[{"award-number":["2017-A019-0215"]}],"id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Terpenes are vital metabolites found in various plants and animals and known to be beneficial in the treatment of various diseases. Previously, our group identified terpenes that increased the survival of Alzheimer\u2019s disease (AD) model flies expressing human amyloid <jats:italic>\u03b2<\/jats:italic> (A<jats:italic>\u03b2<\/jats:italic>) and identified linalool as a neuroprotective terpene against A<jats:italic>\u03b2<\/jats:italic> toxicity. Linalool is a monoterpene that is commonly present as a constituent in essential oils from aromatic plants and is known to have anti\u2010inflammatory, anticancer, antihyperlipidemia, antibacterial, and neuroprotective properties. Although several studies have shown the beneficial effect of linalool in AD animal models, the mechanisms underlying the beneficial effect of linalool on AD are yet to be elucidated. In the present study, we showed that linalool intake increased the survival of the AD model flies during development in a dose\u2010dependent manner, while the survival of wild\u2010type flies was not affected even at high linalool concentrations. Linalool also decreases A<jats:italic>\u03b2<\/jats:italic>\u2010induced apoptosis in eye discs as well as the larval brain. Moreover, linalool intake was found to reduce neurodegeneration in the brain of adult AD model flies. However, linalool did not affect the total amount of A<jats:italic>\u03b2<\/jats:italic>42 protein or A<jats:italic>\u03b2<\/jats:italic>42 aggregation. Rather, linalool decreased A<jats:italic>\u03b2<\/jats:italic>\u2010induced ROS levels, oxidative stress, and inflammatory response in the brains of AD model flies. Furthermore, linalool attenuated the induction of oxidative stress and gliosis by A<jats:italic>\u03b2<\/jats:italic><jats:sub>1-42<\/jats:sub> treatment in the rat hippocampus. Taken together, our data suggest that linalool exerts its beneficial effects on AD by reducing A<jats:italic>\u03b2<\/jats:italic>42\u2010induced oxidative stress and inflammatory reactions.<\/jats:p>","DOI":"10.1155\/2021\/8887716","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T19:35:09Z","timestamp":1615491309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Linalool Alleviates A<i>\u03b2<\/i>42\u2010Induced Neurodegeneration via Suppressing ROS Production and Inflammation in Fly and Rat Models of Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-4128","authenticated-orcid":false,"given":"Chunyu","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-864X","authenticated-orcid":false,"given":"Myeongcheol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-713X","authenticated-orcid":false,"given":"Youngjae","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-0446","authenticated-orcid":false,"given":"Byoungyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-4751","authenticated-orcid":false,"given":"Seokhui","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8503-5277","authenticated-orcid":false,"given":"Chaejin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-467X","authenticated-orcid":false,"given":"Hye Sup","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-8516","authenticated-orcid":false,"given":"Im-Soon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7582-2549","authenticated-orcid":false,"given":"So-Yoon","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-8269","authenticated-orcid":false,"given":"Kyoung Sang","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"World Alzheimer Report 2018: The State of the Art of Dementia Research: New Frontiers","author":"Patterson C.","year":"2018"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02173-6"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200307004-00005"},{"key":"e_1_2_10_8_2","first-page":"211","article-title":"Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer\u2032s disease: a systematic review and meta-analysis","volume":"3","author":"Hansen R. 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