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Intracranial aneurysm (IA) is a fatal disease owing to vascular rupture and subarachnoid hemorrhage. Much attention has been given to circular RNAs (circRNAs) because they may be potential biomarkers for many diseases, but their mechanism in the formation of IA remains unknown. Methods. circRNA expression profile analysis of blood samples was conducted between patients with IA and controls. Overall, 235 differentially expressed circRNAs were confirmed between IA patients and the control group. The reliability of the microarray results was demonstrated by quantitative real-time polymerase chain reaction (qRT-PCR). Results. Of 235 differentially expressed genes, 150 were upregulated, while the other 85 were downregulated. Five miRNAs matched to every differential expression of circRNAs, and related MREs were predicted. We performed gene ontology (GO) analysis to identify the functions of their targeted genes, with the terms \u201cHomophilic cell adhesion via plasma membrane adhesion molecules\u201d and \u201cPositive regulation of cellular process\u201d showing the highest fold enrichment. Conclusions. This study demonstrated the role of circRNA expression profiling in the formation of IA and revealed that the mTOR pathway can be a latent therapeutic strategy for IA.<\/jats:p>","DOI":"10.1155\/2021\/8889569","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T01:35:11Z","timestamp":1611970511000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-829X","authenticated-orcid":true,"given":"Yonggang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-1917","authenticated-orcid":true,"given":"Baoqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Weifang Yidu Central Hospital, 4138 Linglongshan Road, Qingzhou, Shandong Province, 262500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-4971","authenticated-orcid":true,"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-5390","authenticated-orcid":true,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-5315","authenticated-orcid":true,"given":"Maogui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-0255","authenticated-orcid":true,"given":"Jizong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70109-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.84"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532556"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.09.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000170710.95689.41"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1044-z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000141415.28155.46"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143077.23367.18"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206153.92675.b9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1086\/323614"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1086\/426953"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.11.014"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2002.129598"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.04.007"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.01.001"},{"issue":"13","key":"16","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.3760\/cma.j.issn.0366-6999.20130395","article-title":"Intraoperative microvascularDoppler monitoring in intracranial aneurysm surgery","volume":"126","author":"P. 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