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The association between hepatitis C virus (HCV) and oral lichen planus (OLP) is well known, but the association with periodontal disease has been reported less often. The purpose of this study was to investigate the effects of periodontal bacteria and OLP lesions before and after HCV elimination. Subjects and Methods. The subjects were four OLP patients (mean age 72.5 years) with HCV infection. Six types of periodontal bacteria (Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum) were quantified in saliva, and changes in OLP were examined before and after elimination of HCV by antiviral therapy. Biochemical blood tests also were performed. Results. The total number of periodontal bacteria, the numbers of P. gingivalis, T. forsythia, T. denticola, and F. nucleatum, and the risk of presenting with the red-complex bacteria (P. gingivalis, T. forsythia, and T.denticola), leading to periodontal disease progression, decreased after HCV elimination. OLP disappeared in three of the four patients and decreased in the other after sustained virological responses (SVRs). Conclusion. HCV elimination not only improved OLP lesions but also reduced the number of periodontal pathogens and the amount of red-complex periodontal pathogens.<\/jats:p>","DOI":"10.1155\/2021\/8925879","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T20:50:08Z","timestamp":1636663808000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Hepatitis C Virus Elimination by Direct-Acting Antiviral Agents on the Occurrence of Oral Lichen Planus and Periodontal Pathogen Load: A Preliminary Report"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-660X","authenticated-orcid":true,"given":"Yumiko","family":"Nagao","sequence":"first","affiliation":[{"name":"Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan"},{"name":"Liver Center, Saga University Hospital, Nabeshima, Saga 849-8501, Japan"},{"name":"Tsuji Dental & Oral Surgery Clinic, Shiragane-machi, Omuta, Fukuoka 836-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Tsuji Dental & Oral Surgery Clinic, Shiragane-machi, Omuta, Fukuoka 836-0052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2251-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23691"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1159\/000324525"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(18)30270-x"},{"key":"7","volume-title":"Global Hepatitis Report","author":"World Health Organization","year":"2017"},{"key":"8","volume-title":"Progress Report on Access to Hepatitis C Treatment: Focus on Overcoming Barriers in Low- and Middle-Income Countries","author":"World Health Organization","year":"2018"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.039"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1995.tb01966.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12925"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12128"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02347618"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(99)70595-0"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2016.37"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1159\/000450679"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.19080\/argh.2017.07.555711"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/osi2.1070"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.001"},{"key":"22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/prd.12249","article-title":"A review of the influence of periodontal treatment in systemic diseases","volume":"79","author":"A. 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