{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:31:55Z","timestamp":1792132315901,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":315,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. This meta\u2010analysis of randomized placebo\u2010controlled clinical trials assessed the effect of glucose\u2010like peptide\u20101\u2010receptor agonists (GLP\u20101RA) on the lipid profile and liver enzymes in patients with nonalcoholic fatty liver disease (NAFLD). <jats:italic>Materials and Methods<\/jats:italic>. Randomized placebo\u2010controlled trials investigating GLP\u20101RA on the lipid profile and liver enzymes in patients with NAFLD were searched in PubMed\u2010Medline, Scopus, Web of Science, and Google Scholar databases (from inception to January 2020). A random\u2010effects model and a generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted. Weighted random\u2010effects meta\u2010regression was performed on potential confounders on lipid profile and liver enzyme concentrations. <jats:italic>Results<\/jats:italic>. 12 studies were identified (12 GLP\u20101RA arms; 677 subjects) that showed treatment with GLP\u20101RA reduced alanine transaminase (ALT) concentrations (WMD\u2009=\u2009\u221210.14, 95%CI\u2009=\u2009[\u221215.84, \u22120.44], <jats:italic>P<\/jats:italic> &lt; 0.001), gamma\u2010glutamyl transferase (GGT) (WMD\u2009=\u2009\u221211.53, 95%CI\u2009=\u2009[\u221215.21,\u22127.85], <jats:italic>P<\/jats:italic> &lt; 0.001), and alaline phosphatase (ALP) (WMD\u2009=\u2009\u22128.29, 95%CI\u2009=\u2009[\u221211.34, \u22125.24], <jats:italic>P<\/jats:italic> &lt; 0.001). Aspartate aminotransferase (AST) (WMD\u2009=\u2009\u22122.95, 95% CI\u2009=\u2009[\u22127.26, 1.37], <jats:italic>P<\/jats:italic> = 0.18) was unchanged. GLP\u20101 therapy did not alter triglycerides (TC) (WMD\u2009=\u2009\u22127.07, 95%CI\u2009=\u2009[\u221217.51, 3.37], <jats:italic>P<\/jats:italic> = 0.18), total cholesterol (TC) (WMD\u2009=\u2009\u22121.17 (\u22125.25, 2.91), <jats:italic>P<\/jats:italic> = 0.57), high\u2010density lipoprotein (HDL\u2010C) (WMD\u2009=\u20090.97, 95%CI\u2009=\u2009[\u22121.63, 3.58], <jats:italic>P<\/jats:italic> = 0.46), or low\u2010density lipoprotein (LDL\u2010C) (WMD\u2009=\u2009\u22121.67, 95%CI\u2009=\u2009[\u221210.08, 6.74], <jats:italic>P<\/jats:italic> = 0.69) in comparison with controls. <jats:italic>Conclusion<\/jats:italic>. The results of this meta\u2010analysis suggest that GLP\u20101RA treatment significantly reduces liver enzymes in patients with NAFLD, but the lipid profile is unaffected.<\/jats:p>","DOI":"10.1155\/2021\/8936865","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T14:35:06Z","timestamp":1636727706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["GLP\u20101 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shahla","family":"Rezaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Nowrouzi-Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al-Rasadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13643"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1124"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3435"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13857"},{"key":"e_1_2_9_5_2","volume-title":"Nonalcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function","author":"Schwenger K. 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