{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:14:43Z","timestamp":1791317683592,"version":"4.3.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972576"],"award-info":[{"award-number":["31972576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["6202004"],"award-info":[{"award-number":["6202004"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Probiotics are widely used for protection against stress\u2010induced intestinal dysfunction. Oxidative stress plays a critical role in gastrointestinal disorders. It is established that probiotics alleviate oxidative stress; however, the mechanism of action has not been elucidated. We developed an\n                    <jats:italic>in vitro<\/jats:italic>\n                    intestinal porcine epithelial cells (IPEC\u2010J2) model of oxidative stress to explore the antioxidant effect and potential mode of action of\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    ZLP001. The IPEC\u2010J2 cells were preincubated with and without\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 for 3\u2009h and then exposed to hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) for 4\u2009h. Pretreatment with\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 protected IPEC\u2010J2 cells against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced oxidative damage as indicated by cell viability assays and significantly alleviated apoptosis elicited by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    .\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 pretreatment decreased reactive oxygen species production and the cellular malondialdehyde concentration and increased the mitochondrial membrane potential compared with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    treatment alone, suggesting that\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 promotes the maintenance of redox homeostasis in the cells. Furthermore,\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 regulated the expression and generation of some antioxidant enzymes, thereby activating the antioxidant defense system. Treatment with\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 led to nuclear erythroid 2\u2010related factor 2 (Nrf2) enrichment in the nucleus compared with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    treatment alone. Knockdown of Nrf2 significantly weakened the alleviating effect of\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 on antioxidant stress in IPEC\u2010J2 cells, suggesting that Nrf2 is involved in the antioxidative effect of\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001. Collectively, these results indicate that\n                    <jats:italic>L. plantarum<\/jats:italic>\n                    ZLP001 is a promising probiotic bacterium that can potentially alleviate oxidative stress.\n                  <\/jats:p>","DOI":"10.1155\/2021\/8936907","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T23:05:05Z","timestamp":1627772705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<i>Lactobacillus plantarum<\/i>\n                    Exhibits Antioxidant and Cytoprotective Activities in Porcine Intestinal Epithelial Cells Exposed to Hydrogen Peroxide"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5246-7030","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2006.06.005"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058115"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731115002967"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.7.3.2019.0152"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf506326t"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050521"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1801944"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf981149l"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03072.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018-14989"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4241-7"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-8032-4"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14200"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.5897\/ajb11.255"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2012.12079"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5403761"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00060"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016859"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6342"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5987183"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7386239"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.01.185"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3542"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01953"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00508-2"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2031-y"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1034-4"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180719145819"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237182"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.09.010"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.001"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02801-7"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.10.020"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3801"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105122"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022945107762"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.11.053"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5252-8"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01131"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715761003758114"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5480267"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/15230860260220120"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.4.274"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2014"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.04.036"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6028606"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14189"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-010-1255-1"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297911040031"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.006"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo30316k"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/206732"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.385"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177106"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.04.011"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00202.2007"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/8936907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/8936907.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/8936907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:25:02Z","timestamp":1723040702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/8936907"}},"subtitle":[],"editor":[{"given":"Tongxing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/8936907"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8936907","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8936907"}}