{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:19Z","timestamp":1791434239507,"version":"4.3.3"},"reference-count":192,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"900th Hospital of Logistic Support Force Project","award":["2018Q08"],"award-info":[{"award-number":["2018Q08"]}]},{"name":"900th Hospital of Logistic Support Force Project","award":["2019YXK055"],"award-info":[{"award-number":["2019YXK055"]}]},{"DOI":"10.13039\/501100007054","name":"Second Military Medical University","doi-asserted-by":"publisher","award":["2018Q08"],"award-info":[{"award-number":["2018Q08"]}],"id":[{"id":"10.13039\/501100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007054","name":"Second Military Medical University","doi-asserted-by":"publisher","award":["2019YXK055"],"award-info":[{"award-number":["2019YXK055"]}],"id":[{"id":"10.13039\/501100007054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:p>The treatment of bone metastases is a thorny issue. Immunotherapy may be one of the few hopes for patients with unresectable bone metastases. Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. On this basis, we expounded the clinical application of immune checkpoint inhibitors for bone metastasis of common tumors, including non-small-cell lung cancer, renal cell carcinoma, prostate cancer, melanoma, and breast cancer. Then, the deficiencies and limitations in current researches were summarized. In-depth basic research on bone metastases and optimization of clinical treatment is needed.<\/jats:p>","DOI":"10.1155\/2021\/8970173","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T21:05:07Z","timestamp":1638133507000},"page":"1-18","source":"Crossref","is-referenced-by-count":52,"title":["Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-6091","authenticated-orcid":true,"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"},{"name":"Department of Orthopedics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, Fujian Province 350025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-9259","authenticated-orcid":true,"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-4993","authenticated-orcid":true,"given":"Jianchun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-2671","authenticated-orcid":true,"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China"},{"name":"Department of Orthopedics, The Third Affiliated Hospital, Naval Medical University (Second Military Medical University), Shanghai 201805, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3618"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00331-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07313-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.11.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109996"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.01.001"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.05.018"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.011"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.23736\/S1824-4785.19.03193-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00339"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000491"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2015.32"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43414"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.005"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27439"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/cmi.2011.47","article-title":"Bone marrow and the control of immunity","volume":"9","author":"E. Zhao","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00461.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-018-0373-9"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1987"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.678"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.636"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.240"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/nri3175"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00247"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2735"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/720504"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00236"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0474"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.10.016"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061775"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1186\/ar2936"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.02.002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/art.23138"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.10.011"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-255026"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2294"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803897"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403449"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.004"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/nature10783"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00185-6"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020784"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1528"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.07.004"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0578-1"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3055"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.029"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.008"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2012.96"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027090"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3950"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506517102"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.059"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.016"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0392-8"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1593805"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2664"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1387706"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133334"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.029447"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041121"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0740-2"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15028"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102896"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.05.005"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.036"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0506"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3133"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0617"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0753-3"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.017"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2213"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1002\/path.4180"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v4.i4.186"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3379"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0154"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30663-1"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516633189"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210835"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27550"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03460-y"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7039"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1038\/nm1518"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.209"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-020-01182-2"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.3572"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1431088"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0606"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20138-8"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0793-8"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910231"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4771"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.07.020"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318206a1e3"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1823779"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1847-x"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-019-00882-5"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2012.12.004"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1471"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2187"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.04.022"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02613-9"},{"key":"106","first-page":"1","article-title":"Bone metastases, skeletal-related events, and survival in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors","volume":"1","author":"A. Qin","year":"2021","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252537"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0175"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2019.01279"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107033"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192227"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13597"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102085"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01098"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-018-2239-4"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11856"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-017-0315-9"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12505"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14933"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.04.026"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2020.100275"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2019.11.008"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13594"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2016.05.017"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr362"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083026"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2020.06.003"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.10.023"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.4809"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510665"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.02.010"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816714"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816047"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.1985"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30723-8"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.04.042"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.08.007"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14461"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyaa232"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02288-9"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5531"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.12130"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14913"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2018.04.013"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0043"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5578-4"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2926"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.039"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70189-5"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.1584"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.08.007"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30789-X"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001294"},{"key":"156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CE.S54712","article-title":"Sipuleucel-T in the treatment of prostate cancer: an evidence-based review of its place in therapy","volume":"10","author":"J. N. Graff","year":"2014","journal-title":"Core Evidence"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001065"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00884"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/647684"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8020203"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0712"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0664"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000689"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000459"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1480301"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02353-5"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000395"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9820"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6311-z"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001558"},{"key":"173","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.05.013"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32599"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207570"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.1586\/era.12.177"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14681"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.10.004"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2019.02.008"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.12.007"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017832"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0357-3"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.02.006"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00906-9"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071631"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1038\/nature14011"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-018-1254-3"},{"key":"189","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1259-z"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00007-8"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13875"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR08024A"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2021\/8970173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2021\/8970173.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2021\/8970173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T21:05:33Z","timestamp":1638133533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2021\/8970173\/"}},"subtitle":[],"editor":[{"given":"Xiao-Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,28]]},"references-count":192,"alternative-id":["8970173","8970173"],"URL":"https:\/\/doi.org\/10.1155\/2021\/8970173","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"value":"2314-7156","type":"electronic"},{"value":"2314-8861","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,28]]}}}