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Through a cell\u2010based peroxisome proliferator responsive element\u2010 (PPRE\u2010) driven luciferase bioassay, we have investigated 145 examples of traditional Chinese medicines (TCMs). Several TCMs, such as <jats:italic>Polygonum cuspidatum<\/jats:italic>, <jats:italic>Rheum officinale<\/jats:italic> Baillon, and <jats:italic>Aloe vera<\/jats:italic> var. Chinensis (Haw.) Berg., were found to possess high activity. We have further detected the anti\u2010IAV activities of emodin (EMO) and its analogs, a group of common important compounds of these TCMs. The results showed that emodin and its several analogs possess excellent anti\u2010IAV activities. The pharmacological tests showed that emodin significantly activated PPAR<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b3<\/jats:italic> and AMPK, decreased fatty acid biosynthesis, and increased intracellular ATP levels. Pharmaceutical inhibitors, siRNAs for PPAR<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b3<\/jats:italic> and AMPK<jats:italic>\u03b1<\/jats:italic>1, and exogenous palmitate impaired the inhibition of emodin. The in vivo test also showed that emodin significantly protected mice from IAV infection and pneumonia. Pharmacological inhibitors for PPAR<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b3<\/jats:italic> and AMPK signal and exogenous palmitate could partially counteract the effects of emodin in vivo. In conclusion, emodin and its analogs are a group of promising anti\u2010IAV drug precursors, and the pharmacological mechanism of emodin is linked to its ability to regulate the PPAR<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b3<\/jats:italic>\u2010AMPK pathway and fatty acid metabolism.<\/jats:p>","DOI":"10.1155\/2021\/9066938","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T18:21:55Z","timestamp":1631211715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti\u2010influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPAR<i>\u03b1<\/i>\/<i>\u03b3<\/i>\u2010AMPK\u2010SIRT1 Pathway and Fatty Acid Metabolism"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-3053","authenticated-orcid":false,"given":"Yufei","family":"Bei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Tia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-8207","authenticated-orcid":false,"given":"Jianping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0567-0"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00219-07"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir804"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0748-0"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.44"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.007"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.243261"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.02.007"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029879"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2010.09.019"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1500"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25199"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101754"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00738.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1087057106296498"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00759-13"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1087057111435236"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9303-y"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5631"},{"key":"e_1_2_10_21_2","first-page":"3937","article-title":"Research progress in anti-tumor effect of emodin","volume":"40","author":"Lin W. 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