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The present study examined the effect of electroacupuncture (EA) on noise-induced hearing loss (NIHL) in animals. A NIHL rat model was established. Electroacupuncture pretreatment at 2\u2009Hz or posttreatment at the right Zhongzhu (TE3) acupoint was applied for 1 hour. Auditory thresholds were measured using auditory brainstem responses (ABRs), and histopathology of the cochlea was examined. The results indicated that the baseline auditory threshold of ABR was not significantly different between the control (no noise), EA-only (only EA without noise), noise (noise exposure only), pre-EA (pretreating EA then noise), and post-EA (noise exposure then posttreating with EA) groups. Significant auditory threshold shifts were found in the noise, pre-EA, and post-EA groups in the immediate period after noise exposure, whereas auditory recovery was better in the pre-EA and post-EA groups than that in the noise group at the three days, one week (W1), two weeks (W2), three weeks (W3), and four weeks(W4) after noise stimulation. Histopathological examination revealed greater loss of the density of spiral ganglion neurons in the noise group than in the control group at W1 and W2. Although significant loss of spiral ganglion loss happened in pre-EA and post-EA groups, such loss was less than the loss of the noise group, especially W1. These results indicate that either pretreatment or posttreatment with EA may facilitate auditory recovery after NIHL. The detailed mechanism through which EA alleviates NIHL requires further study.<\/jats:p>","DOI":"10.1155\/2021\/9114676","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T22:20:20Z","timestamp":1635373220000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Electroacupuncture on Noise-Induced Hearing Loss in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-8627","authenticated-orcid":true,"given":"Chia-Hao","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan"},{"name":"Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Division of Otorhinolaryngology, China Medical University Hospital, Taipei Branch, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-6821","authenticated-orcid":true,"given":"Chia-Der","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan"},{"name":"School of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-4716","authenticated-orcid":true,"given":"Ching-Liang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan"},{"name":"Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Chinese Medicine Research Center, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2019.80.9.525"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0219-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-020-00906-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1121\/1.5134465"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.11.013"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.21848\/asr.2016.12.s1.s14"},{"key":"7","article-title":"Noise-induced hearing loss treatment: systematic review and meta-analysis","author":"M. 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