{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:51:03Z","timestamp":1793393463466,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2017Y9099"],"award-info":[{"award-number":["2017Y9099"]}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["NCETFJ-2017B015"],"award-info":[{"award-number":["NCETFJ-2017B015"]}]},{"name":"Program for New Century Excellent Talents in Fujian Province University","award":["2017Y9099"],"award-info":[{"award-number":["2017Y9099"]}]},{"name":"Program for New Century Excellent Talents in Fujian Province University","award":["NCETFJ-2017B015"],"award-info":[{"award-number":["NCETFJ-2017B015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Studies have reported that <jats:italic>B-<\/jats:italic> and <jats:italic>T-lymphocyte attenuator<\/jats:italic> (<jats:italic>BTLA<\/jats:italic>) polymorphisms may be associated with the risk to different cancers. However, the correlation between those variations and non\u2010small\u2010cell lung cancer (NSCLC) is still unclear. A total of 1,003 NSCLC patients and 901 noncancer controls were recruited in the study, to confirm the association of variations in <jats:italic>BTLA<\/jats:italic> gene with the risk of NSCLC. The SNPscan\u2122 genotyping assay was used to obtain the genotypes of the four BTLA polymorphisms (<jats:italic>BTLA<\/jats:italic> rs1982809 G&gt;A, rs16859629 T&gt;C, rs2171513 G&gt;A, and rs3112270 A&gt;G). It was found that <jats:italic>BTLA<\/jats:italic> rs1982809 polymorphism reduced the risk of NSCLC (GA vs. GG: adjusted\u2009odds\u2009ratio\u2009(OR) = 0.81, 95<jats:italic>%<\/jats:italic>confidence\u2009interval\u2009(CI) = 0.66\u20100.99, and <jats:italic>P<\/jats:italic> = 0.043). However, the <jats:italic>BTLA<\/jats:italic> rs16859629, rs2171513, and rs3112270 polymorphisms showed no significant association between NSCLC patients and controls in overall comparison. In subgroup analyses, we found that <jats:italic>BTLA<\/jats:italic> rs1982809 polymorphism reduced the risk of NSCLC (nonsquamous cell carcinoma: GA vs. GG: adjusted\u2009OR = 0.79, 95<jats:italic>%<\/jats:italic>CI = 0.64\u20100.97, and <jats:italic>P<\/jats:italic> = 0.026; AA\/GA vs. GG: adjusted\u2009OR = 0.81, 95<jats:italic>%<\/jats:italic>CI = 0.66\u20100.99, and <jats:italic>P<\/jats:italic> = 0.037; \u226559 years: GA vs. GG: <jats:italic>P<\/jats:italic> = 0.036; never alcohol consumption: GA vs. GG: <jats:italic>P<\/jats:italic> = 0.013; GA\/AA vs. GG: <jats:italic>P<\/jats:italic> = 0.016; body\u2009mass\u2009index\u2009(BMI) \u2265 24\u2009kg\/m<jats:sup>2<\/jats:sup>: GA vs. GG: <jats:italic>P<\/jats:italic> = 0.030; GA\/AA vs. GG: <jats:italic>P<\/jats:italic> = 0.041). The <jats:italic>BTLA<\/jats:italic> rs16859629 polymorphism increased the risk of the development of squamous cell carcinoma (CC vs. TT: adjusted\u2009OR = 9.85, 95<jats:italic>%<\/jats:italic>CI = 1.37\u201071.03, and <jats:italic>P<\/jats:italic> = 0.023; CC vs. TT\/TC: adjusted\u2009OR = 9.55, 95<jats:italic>%<\/jats:italic>CI = 1.32\u201068.66, and <jats:italic>P<\/jats:italic> = 0.025). Taken together, the findings of the present suggest that <jats:italic>BTLA<\/jats:italic> rs1982809 and rs16859629 polymorphisms may influence the susceptibility to NSCLC in the Chinese population.<\/jats:p>","DOI":"10.1155\/2021\/9121824","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T16:50:07Z","timestamp":1612025407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of <i>BTLA<\/i> Polymorphisms with Susceptibility to Non\u2010Small\u2010Cell Lung Cancer in the Chinese 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