{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:04:15Z","timestamp":1793703855717,"version":"4.5.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence.\n                    <jats:italic>Aim<\/jats:italic>\n                    . To map the incidence and prevalence of PBC in European countries from 2000 through 2020.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Following PRISMA recommendations, we searched the Medline and Scopus databases for studies with information on either the incidence or prevalence of PBC. After data extraction, we used a random\u2010effects model to estimate both the pooled annual incidence rate and pooled point\u2010prevalence rate and performed subgroup analyses to identify components contributing to between\u2010study heterogeneity.\n                    <jats:italic>Results<\/jats:italic>\n                    . We performed a qualitative and quantitative analysis of 18 studies. The pooled point\u2010prevalence rate was 22.27 cases per 100,000 inhabitants (95% CI: 17.98\u201327.01), and the pooled annual incidence rate was 1.87 new cases per 100,000 inhabitants (95% CI: 1.46\u20132.34). In the subgroup analyses, we proved that a small part of the between\u2010study heterogeneity is significantly associated with a history of being part of the Eastern Bloc.\n                  <\/jats:p>","DOI":"10.1155\/2021\/9151525","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T18:50:13Z","timestamp":1624301413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-2217","authenticated-orcid":false,"given":"Jakub","family":"Gazda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-6757","authenticated-orcid":false,"given":"Sylvia","family":"Drazilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-3968","authenticated-orcid":false,"given":"Martin","family":"Janicko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-9984","authenticated-orcid":false,"given":"Peter","family":"Jarcuska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697617"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21076"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/546926"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8656-x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.05.006"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.033"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15329"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09984-x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701396034"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0b013e328277594a"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.05.002"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0b013e328353753d"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt308"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12479"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12434"},{"key":"e_1_2_9_18_2","article-title":"Prevalence and epidemiology of autoimmune hepatitis and primary biliary cirrhosis across the South-Eastern regional health board","volume":"184","author":"Heetun Z.","year":"2015","journal-title":"Proceedings of the Irish Journal of Medical Science"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25906"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2017.05.006"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2018.5665\/2018"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.11.008"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2019.60.494"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47890-2"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-020-01391-6"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1135-9306"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.019"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/824396"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036558"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000440705"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1509840"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1714519"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2021\/9151525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2021\/9151525.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/9151525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:44:01Z","timestamp":1758786241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9151525"}},"subtitle":[],"editor":[{"given":"Laura","family":"Turco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/9151525"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9151525","archive":["Portico"],"relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9151525"}}