{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:39:29Z","timestamp":1791758369557,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["428701\/2018-3"],"award-info":[{"award-number":["428701\/2018-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Exhaustive and acute unusual physical exercise leads to muscle damage. Curcumin has been widely studied due to the variety of its biological activities, attributed to its antioxidant and anti\u2010inflammatory properties. Furthermore, it has shown positive effects on physical exercise practitioners. However, there is no literature consensus on the beneficial effects of curcumin in acute physical activities performed by sedentary individuals. Therefore, we systematically reviewed evidence from clinical trials on the main effects of curcumin supplementation on inflammatory markers, sports performance, and muscle damage during acute physical exercises in these individuals. We searched PubMed\/MEDLINE, Scopus, Web of Science, and Embase databases, and only original studies were analyzed according to the PRISMA guidelines. The included studies were limited to supplementation of curcumin during acute exercise. A total of 5 studies were selected. Methodological quality assessments were examined using the SYRCLE\u2019s risk\u2010of\u2010bias tool. Most studies have shown positive effects of curcumin supplementation in sedentary individuals undergoing acute physical exercise. Overall, participants supplemented with curcumin showed less muscle damage, reduced inflammation, and better muscle performance. The studies showed heterogeneous data and exhibited methodological limitations; therefore, further research is necessary to ensure curcumin supplementation benefits during acute and high\u2010intensity physical exercises. Additionally, mechanistic and highly controlled studies are required to improve the quality of the evidence and to elucidate other possible mechanisms. This study is registered with Prospero number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42021262718\">CRD42021262718<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2021\/9264639","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T16:32:48Z","timestamp":1633883568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Curcumin Supplementation on Inflammatory Markers, Muscle Damage, and Sports Performance during Acute Physical Exercise in Sedentary Individuals"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-0348","authenticated-orcid":false,"given":"Kelly Aparecida","family":"Dias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2709-6682","authenticated-orcid":false,"given":"Aline Rosignoli","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-633X","authenticated-orcid":false,"given":"L\u00edvya Alves","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-0806","authenticated-orcid":false,"given":"Stephanie Michelin Santana","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6999-0060","authenticated-orcid":false,"given":"Stefany da Silva","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-6023","authenticated-orcid":false,"given":"Larissa Farias","family":"Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-7877","authenticated-orcid":false,"given":"Mari\u00e1urea Matias","family":"Sarandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-5328","authenticated-orcid":false,"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-3590","authenticated-orcid":false,"given":"Reggiani Vilela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-5694","authenticated-orcid":false,"given":"Ceres Mattos","family":"Della Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18021741"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3170-4"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13373"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199205000-00005"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S114635"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-11-31"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-014-0066-3"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-019-04213-7"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.01005.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181b64edd"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.41.1640"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077195"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9432-8"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101553"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4533"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2019.1604604"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S110873"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.65.82"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8647587"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2016.02.003"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2015.11.022"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200004000-00011"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4209-8"},{"key":"e_1_2_10_26_2","article-title":"Import\u00e2ncia dos efeitos fisiol\u00f3gicos do exerc\u00edcio na promo\u00e7\u00e3o da sa\u00fade","volume":"1","author":"Lira F. S.","year":"2012","journal-title":"Inova Sa\u00fade"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1754754"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636040-00004"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7239639"},{"key":"e_1_2_10_30_2","first-page":"63","volume-title":"In The Science of Hormesis in Health and Longevity","author":"Radak Z.","year":"2018"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31802f04f6"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5773"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2924"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.116"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2014.917749"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.07.006"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.02.008"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.7199"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-26"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.8.899"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200737100-00001"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030500"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00333.x"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.11138\/mltj\/2013.3.4.337"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10126SC"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.842"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020501"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.09.002"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.3705"},{"key":"e_1_2_10_50_2","first-page":"226","article-title":"Metabolismo Do Lactato: Uma Revis\u00e3o Sobre a Bioenerg\u00e9tica e a Fadiga Muscular","volume":"11","author":"de Moraes Bertuzzi R. C.","year":"2009","journal-title":"Revista Brasileira de Cineantropometria e Desempenho Humano"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7020905"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.06.015"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.010"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.112"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.208728"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4715"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.005"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509993667"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a117"},{"key":"e_1_2_10_60_2","first-page":"29","article-title":"Meta-analysis in medical research","volume":"14","author":"Haidich A. B.","year":"2010","journal-title":"Hippokratia"},{"key":"e_1_2_10_61_2","unstructured":"SterneJ. A. C. EggerM. MoherD. andBoutronI. HigginsJ. P. T. ChurchillR. ChandlerJ. andCumpstonM. S. Chapter 10: Addressing reporting biases Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017) Cochrane 2017 https:\/\/training.cochrane.org\/sites\/training.cochrane.org\/files\/public\/uploads\/resources\/Handbook5_1\/Chapter_10_Handbook_5_2_10.pdf."},{"key":"e_1_2_10_62_2","unstructured":"HigginsJ. P. T. ThomasJ. ChandlerJ. CumpstonM. LiT. andPageM. J. WelchV. A. Cochrane Handbook for Systematic Reviews of Interventions The Cochrane Collaboration https:\/\/handbook-5-1.cochrane.org\/chapter_10\/10_4_3_1_recommendations_on_testing_for_funnel_plot_asymmetry.htm."},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9264639.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9264639.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/9264639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:13:51Z","timestamp":1723054431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9264639"}},"subtitle":[],"editor":[{"given":"Dragan","family":"Hrn\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/9264639"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9264639","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9264639"}}