{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:05:56Z","timestamp":1766869556160,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002769","name":"Bushehr University of Medical Sciences","doi-asserted-by":"publisher","award":["461"],"award-info":[{"award-number":["461"]}],"id":[{"id":"10.13039\/501100002769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Knowledge regarding the prevalence and risk factors of hepatitis C virus (HCV) infection among pregnant women can give clue to health care providers regarding the appropriate management of HCV infection. Therefore, this study was conducted to determine the prevalence, genotypic pattern, and risk factors of HCV infection among pregnant women in the northern shores of the Persian Gulf, south of Iran. <jats:italic>Methods<\/jats:italic>. From January 2018 to June 2019, serum samples were obtained from 1425 pregnant women, ages ranging from 14 to 46 years (28.1 \u00b1 5.99). Serum samples were tested for detection of anti\u2010HCV antibodies using an enzyme\u2010linked immunosorbent assay (ELISA) (HCV Ab ELISA kit, Dia.Pro, Milan, Italy). Following the extraction of nucleic acid, the molecular evaluation of HCV infection was performed by seminested reverse transcriptase\u2010polymerase chain reaction assay (RT\u2010PCR), targeting the 5\u2009<jats:sup>\u2032<\/jats:sup> untranslated region (5\u2009<jats:sup>\u2032<\/jats:sup>UTR) and core of HCV genome and sequencing. <jats:italic>Results<\/jats:italic>. Of the 1425 pregnant women, 19 women (1.33%, 95% CI: 0.85%\u20132.07%) were positive for anti\u2010HCV antibodies. The majority of HCV\u2010seropositive women were in the third trimester of pregnancy, educated, and had a history of blood transfusion, abortion, surgery, or dentistry. Moreover, Arab and Fars pregnant women and those aged &gt;39 years had the highest rate of HCV seroprevalence. Nevertheless, none of these variables were significantly associated with HCV seropositivity. In contrast, HCV seropositivity was associated with place of residency, so that residents of Khormuj city had significantly higher HCV seroprevalence compared to the residents of other cities (OR: 7.05; 95% CI: 1.75\u201328.39; <jats:italic>P<\/jats:italic> = 0.006). According to the molecular evaluation, 9 of the 19 HCV\u2010seropositive pregnant women (47.37%) had HCV viremia with genotype 3a. <jats:italic>Conclusion<\/jats:italic>. This study reports the HCV prevalence of 1.33% for anti\u2010HCV antibodies and 0.63% for HCV RNA among pregnant women in the south of Iran. Considering the asymptomatic nature of chronic HCV infection and the fact that vertical transmission is possible in women with detectable viremia, therefore, screening of women before pregnancy is recommended to reduce the risk of HCV infection and its complications during pregnancy.<\/jats:p>","DOI":"10.1155\/2021\/9294276","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T04:20:13Z","timestamp":1632198013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and Predominant Genotype of Hepatitis C Virus Infection and Associated Risk Factors among Pregnant Women in Iran"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-9573","authenticated-orcid":false,"given":"Fatemeh","family":"Farshadpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-0531","authenticated-orcid":false,"given":"Reza","family":"Taherkhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8743-6218","authenticated-orcid":false,"given":"Farkhondeh","family":"Bakhtiari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i33.1239"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i1.42"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S183462"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0897-y"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1382"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230109"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1665-2681(19)31731-4"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2016.00067"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu447"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.027"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-2-201301150-00575"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v6.i9.643"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.00968.x"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.83644"},{"key":"e_1_2_11_15_2","first-page":"674","article-title":"Prevalence and trend of hepatitis C virus infection among blood donors in Iran: a systematic review and meta-analysis","volume":"18","author":"Khodabandehloo M.","year":"2013","journal-title":"Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.42291"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488985"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157615"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1709185"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1282"},{"key":"e_1_2_11_21_2","first-page":"138","article-title":"Seroprevalence of hepatitis C, hepatitis B and HIV and co-infection among pregnant women: a retrospective study in 2006 at Malekan city, Iran","volume":"1","author":"Sahaf F.","year":"2007","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.5812\/kowsar.1735143X.1965"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2020.1784456"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422x-4-104"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7917894"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-116"},{"key":"e_1_2_11_27_2","first-page":"221","article-title":"Seroprevalence of hepatitis B and C, and human immunodeficiency viruses in Saudi pregnant women and rates of vertical transmission","volume":"47","author":"Al-Mandeel H. 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