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Although various innovative techniques and drugs have been developed for treating DFUs, therapeutic outcomes remain unsatisfactory. Using the GEO database, we obtained transcriptomic microarray data for DFUs and control wounds and detected a significant downregulation of epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) in DFUs. We cultured human umbilical vein endothelial cells (HUVECs) and noted downregulated <jats:italic>EGFR<\/jats:italic> expression following high\u2010glucose exposure <jats:italic>in vitro<\/jats:italic>. Further, we observed decreased HUVEC proliferation and migration and increased apoptosis after shRNA\u2010mediated <jats:italic>EGFR<\/jats:italic> silencing in these cells. In mice, <jats:italic>EGFR<\/jats:italic> inhibition via focal EGFR\u2010shRNA injection delayed wound healing. Target prediction analysis followed by dual\u2010luciferase reporter assays indicated that microRNA\u2010133b (miR\u2010133b) is a putative upstream regulator of <jats:italic>EGFR<\/jats:italic> expression. Increased miR\u2010133b expression was observed in both glucose\u2010treated HUVECs and wounds from diabetes patients, but no such change was observed in controls. miR\u2010133b suppression enhanced the proliferation and angiogenic potential of cultured HUVECs and also accelerated wound healing. Although angiogenesis is not the sole mechanism affected in DFU, these findings suggest that the miR\u2010133b\u2010induced downregulation of <jats:italic>EGFR<\/jats:italic> may contribute to delayed wound healing in diabetes. Hence, miR\u2010133b inhibition may be a useful strategy for treating diabetic wounds.<\/jats:p>","DOI":"10.1155\/2021\/9306760","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T17:05:10Z","timestamp":1638032710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["[Retracted] MicroRNA\u2010133b Inhibition Restores EGFR Expression and Accelerates Diabetes\u2010Impaired Wound 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