{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:43:33Z","timestamp":1747190613353,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:p>Introduction. Hypoxic-ischemic encephalopathy (HIE) is defined as a neurological complication that results from perinatal asphyxia. Previous studies had investigated various markers to early detect HIE; however, these markers appeared to have several drawbacks, especially in resource-limited settings. Aim. This study aimed at evaluating the predictive value of the salivary lactate dehydrogenase level as a potential predictor of hypoxic-ischemic encephalopathy for newborns. Materials and Methods. We included 30 neonates with HIE due to perinatal asphyxia and 30 healthy newborns that serve as controls, admitted at the intensive care unit for neonates and maternity ward at Ismailia area Clinics and Hospitals. We measured the LDH levels by using saliva samples that were collected for neonates maximum by 12\u2009h after birth. Results. It was found that patients with HIE had a statistically significant higher salivary LDH level (1927\u2009\u00b1\u2009390.3\u2009IU\/L) than patients without HIE (523.6\u2009\u00b1\u2009142.8\u2009IU\/L) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Moreover, salivary LDH showed a good discriminative ability where the AUC was 0.966 regarding salivary LDH (95% CI: 0.917\u20131.0) (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The best cutoff value was 1420\u2009IU\/L or more which showed the best results in predicting the occurrence of HIE with 98.3% and 97.6% sensitivity and specificity, respectively. Conclusion. Salivary LDH can be considered as a useful noninvasive laboratory marker that can accurately predict HIE incidence among neonates with asphyxia within 12 hours from birth. The cases in the HIE group were assigned into three stages according to the Sarnat and Sarnat staging system: stage I: mild (irritable, normal, or hypertonia and poor feeding); stage II: moderate (lethargy, hypotonia, and frequent seizure); stage III: severe (coma, flaccid, absent reflexes, and frequent seizure). There is a positive association between LDH levels and the severity of HIE.<\/jats:p>","DOI":"10.1155\/2021\/9316277","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T23:26:57Z","timestamp":1631748417000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Lactate Dehydrogenase in Relationship to the Severity of Hypoxic-Ischemic Encephalopathy among Newborn Infants"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-4336","authenticated-orcid":true,"given":"Hend","family":"Elmoursi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bader Eldin","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelmoneim","family":"Khashana","sequence":"additional","affiliation":[{"name":"Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)71048-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/506320"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003311.pub3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/08035250600693488"},{"issue":"1","key":"5","first-page":"62","article-title":"Can biochemical markers predict the severity of hypox-icischemic encephalopathy?","volume":"56","author":"S. Beken","year":"2014","journal-title":"Turkish Journal of Pediatrics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1344966"},{"key":"7","article-title":"Methods of evidence-based medicine and decision analysis","volume":"326","author":"B. 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Karunatilaka","year":"2000","journal-title":"Sri Lanka Journal of Child Health"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02778.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s0377-1237(06)80079-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0181"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1368"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)70932-6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1297"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12726"},{"issue":"2","key":"23","first-page":"1","article-title":"Perinatal asphyxia in the term newborn","volume":"3","author":"R. Antonucci","year":"2014","journal-title":"Journal of Pediatric and Neonatal Individualized Medicine"}],"container-title":["Scientifica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/9316277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/9316277.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/9316277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T23:27:04Z","timestamp":1631748424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/scientifica\/2021\/9316277\/"}},"subtitle":[],"editor":[{"given":"Huaxin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":23,"alternative-id":["9316277","9316277"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9316277","relation":{},"ISSN":["2090-908X"],"issn-type":[{"type":"electronic","value":"2090-908X"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}