{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:43:33Z","timestamp":1747190613100,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2021,5,24]]},"abstract":"<jats:p>Systemic juvenile idiopathic arthritis (sJIA) is characterized by arthritis, fever, rash, lymphadenopathy, hepatosplenomegaly, and serositis. Macrophage activation syndrome is the most feared complication of sJIA with a high risk of mortality. We report a 16-year-old female diagnosed with refractory systemic juvenile idiopathic arthritis (sJIA) complicated by recurrent macrophage activation syndrome (MAS), severe joint disease, and lung involvement requiring prolonged immunosuppressive therapy. She received a matched unrelated allogeneic hematopoietic cell transplant (Allo-HCT) using a reduced-intensity conditioning regimen and is now, 3 years after the transplant, with complete resolution of sJIA symptoms, off immunosuppressants, and with significant improvement in the quality of life.<\/jats:p>","DOI":"10.1155\/2021\/9323141","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T23:20:15Z","timestamp":1621898415000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Allogeneic Hematopoietic Cell Transplant for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome"],"prefix":"10.1155","volume":"2021","author":[{"given":"Nicole","family":"Davidson","sequence":"first","affiliation":[{"name":"Pediatric Residency Program, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemalatha G.","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Oncology, Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyla","family":"Driest","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University, OH, USA"},{"name":"Pediatric Rheumatology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajinder P. 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