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This fact highlights the crucial protective role of the skin. However, the skin itself may not be capable of protecting against UVB depending on irradiation intensity and time of exposition. Sun blockers are used to protect our skin, but they fail to fully protect it against oxidative and inflammatory injuries initiated by UVB. To solve this issue, topical administration of active molecules is an option. 15\u2010Deoxy\u2010\n                    <jats:italic>\u0394<\/jats:italic>\n                    <jats:sup>12,14<\/jats:sup>\n                    \u2010prostaglandin J\n                    <jats:sub>2<\/jats:sub>\n                    (15d\u2010PGJ\n                    <jats:sub>2<\/jats:sub>\n                    ) is an arachidonic acid\u2010derived lipid with proresolution and anti\u2010inflammatory actions. However, as far as we are aware, there is no evidence of its therapeutic use in a topical formulation to treat the deleterious events initiated by UVB, which was the aim of the present study. We used a nonionic cream to vehiculate 15d\u2010PGJ\n                    <jats:sub>2<\/jats:sub>\n                    (30, 90, and 300\u2009ng\/mouse) (TFcPGJ\n                    <jats:sub>2<\/jats:sub>\n                    ) in the skin of hairless mice. UVB increased skin edema, myeloperoxidase activity, metalloproteinase\u20109 activity, lipid peroxidation, superoxide anion production, gp91\n                    <jats:sup>phox<\/jats:sup>\n                    and COX\u20102 mRNA expression, cytokine production, sunburn and mast cells, thickening of the epidermis, and collagen degradation. UVB also diminished skin ability to reduce iron and scavenge free radicals, reduced glutathione (GSH), sulfhydryl proteins, and catalase activity. TFcPGJ\n                    <jats:sub>2<\/jats:sub>\n                    inhibited all these pathological alterations in the skin caused by UVB. No activity was observed with the unloaded topical formulation. The protective outcome of TFcPGJ\n                    <jats:sub>2<\/jats:sub>\n                    indicates it is a promising therapeutic approach against cutaneous inflammatory and oxidative pathological alterations.\n                  <\/jats:p>","DOI":"10.1155\/2021\/9330596","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T19:06:04Z","timestamp":1635879964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Topical Administration of 15\u2010Deoxy\u2010\n                    <i>\u0394<\/i>\n                    <sup>12,14<\/sup>\n                    \u2010Prostaglandin J\n                    <sub>2<\/sub>\n                    Using a Nonionic Cream: Effect on UVB\u2010Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1301-7728","authenticated-orcid":false,"given":"Clovis M.","family":"Kumagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-0876","authenticated-orcid":false,"given":"Renata M.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-9949","authenticated-orcid":false,"given":"Barbara B.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-0559","authenticated-orcid":false,"given":"Priscila","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-0960","authenticated-orcid":false,"given":"Ingrid C.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-0583","authenticated-orcid":false,"given":"Camilla C. 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