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The aim of this paper is to develop a rapid and accurate medical diagnosis support system to detect COVID-19 in chest X-ray images using a stacking approach combining transfer learning techniques and KNN algorithm for selection of the best model. In deep learning, we have multiple approaches for building a classification system for analyzing radiographic images. In this work, we used the transfer learning technique. This approach makes it possible to store and use the knowledge acquired from a pretrained convolutional neural network to solve a new problem. To ensure the robustness of the proposed system for diagnosing patients with COVID-19 using X-ray images, we used a machine learning method called the stacking approach to combine the performances of the many transfer learning-based models. The generated model was trained on a dataset containing four classes, namely, COVID-19, tuberculosis, viral pneumonia, and normal cases. The dataset used was collected from a six-source dataset of X-ray images. To evaluate the performance of the proposed system, we used different common evaluation measures. Our proposed system achieves an extremely good accuracy of 99.23% exceeding many previous related studies.<\/jats:p>","DOI":"10.1155\/2021\/9437538","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T04:05:06Z","timestamp":1636171506000},"page":"1-17","source":"Crossref","is-referenced-by-count":32,"title":["A Novel COVID-19 Diagnosis Support System Using the Stacking Approach and Transfer Learning Technique on Chest X-Ray Images"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-7787","authenticated-orcid":true,"given":"Soufiane","family":"Hamida","sequence":"first","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-9528","authenticated-orcid":true,"given":"Oussama","family":"El Gannour","sequence":"additional","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2016-8682","authenticated-orcid":true,"given":"Bouchaib","family":"Cherradi","sequence":"additional","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"},{"name":"STIE Team, CRMEF Casablanca-Settat, Provincial Section of El Jadida, 24000 El Jadida, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-274X","authenticated-orcid":true,"given":"Abdelhadi","family":"Raihani","sequence":"additional","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-6604","authenticated-orcid":true,"given":"Hicham","family":"Moujahid","sequence":"additional","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ouajji","sequence":"additional","affiliation":[{"name":"SSDIA Laboratory, ENSET of Mohammedia, Hassan II University of Casablanca, BP 159, Mohammedia, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108634"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114184"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2021.102018"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104249"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1109\/CommNet49926.2020.9199642"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s13369-020-04839-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.techfore.2020.120201"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.25046\/aj050533"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6649591"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1109\/ICOTEN52080.2021.9493524"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1109\/CommNet49926.2020.9199620"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1109\/ICECOCS.2018.8610649"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1109\/ICOA.2019.8727688"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2020.100483"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1109\/ATSIP.2017.8075519"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s11042-017-5589-6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.parco.2011.03.001"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1109\/ICoCS.2014.7060986"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1109\/ICOA.2018.8370542"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1109\/ICM.2015.7438002"},{"issue":"3","key":"21","first-page":"368","article-title":"New brain extraction method using expectation maximization and mathematical morphology","volume":"73","author":"S. 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