{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:45:42Z","timestamp":1782769542530,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiology Research and Practice"],"published-print":{"date-parts":[[2021,10,15]]},"abstract":"<jats:p>Objectives. Carotid bodies (CBs) play an important role in regulating sympathetic nervous system activity. Thus, they are likely to be enlarged in patients with certain cardiovascular and respiratory diseases. The aim of this case-control study was to verify this hypothesis using computed tomography angiography (CTA). Methods. We retrospectively analysed 141 CTAs including 16 controls, 96 patients with only hypertension (HT), 12 with HT and previous acute myocardial infarction (AMI), 9 with HT and heart failure (HF), and 8 with HT and chronic obstructive pulmonary disease (COPD). We assessed the data using analysis of variance, with <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> indicating significance. Results. CB average areas in the controls were 2.31\u2009mm2 (right side (RS)) vs. 2.34\u2009mm2 (left side (LS)). CB size was significantly enlarged in patients with HT: 3.07\u2009mm2 (RS) (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.019<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) vs. 2.91\u2009mm2 (LS) (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.002<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). If AMI (RS: 3.5\u2009mm2; LS: 3.44\u2009mm2) or HF (RS: 4.01\u2009mm2; LS: 4.55\u2009mm2) was associated with HT, the CB size was even more enlarged. COPD did not affect CB size (RS: 2.40\u2009mm2; LS: 2.29\u2009mm2). Conclusions. Our data showed that certain diseases with increased activity of the sympathetic nervous system were associated with significantly enlarged CBs.<\/jats:p>","DOI":"10.1155\/2021\/9499420","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T21:59:17Z","timestamp":1634335157000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-4293","authenticated-orcid":true,"given":"S\u00e1ndor","family":"Csizmadia","sequence":"first","affiliation":[{"name":"Affidea Hungary Ltd. Budapest, 44-46 B\u00f3kay J\u00e1nos Street, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-4966","authenticated-orcid":true,"given":"Gergely H.","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Faculty of General Medicine, 9 Kor\u00e1nyi Alley, Szeged H-6725, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-6934","authenticated-orcid":true,"given":"Andr\u00e1s","family":"Palk\u00f3","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Szeged, Faculty of General Medicine, 6 Semmelweis Street, Szeged H-6725, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-2493","authenticated-orcid":true,"given":"Erika","family":"V\u00f6r\u00f6s","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Szeged, Faculty of General Medicine, 6 Semmelweis Street, Szeged H-6725, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1874-9_1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1134\/s0362119706010166"},{"key":"3","first-page":"3067","article-title":"Translating carotid body function into clinical medicine","volume":"596\/15","author":"I. Rodrigo","year":"2018","journal-title":"Journal of Physiology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18440-1_1"},{"key":"5","first-page":"561","article-title":"Peripheral chemoreception and arterial pressure responses to intermittent hypoxia","volume":"5\/2","author":"R. P. Nanduri","year":"2015","journal-title":"Comprehensive Physiology"},{"key":"6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s005400200041","article-title":"Oxygen sensing in the carotid body: inhibited hypoxic respiratory with muscle relaxant","volume":"16","author":"I. Yuichi","year":"2002","journal-title":"Journal of Anesthesia"},{"key":"7","first-page":"2977","article-title":"The role of hypoxia\u2010inducible factors in carotid body (patho) physiology","volume":"596\/15","author":"L. S. Gregg","year":"2018","journal-title":"Journal of Physiology"},{"key":"8","first-page":"1","article-title":"Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia","volume":"5\/468","author":"I. Rodrigo","year":"2014","journal-title":"Frontiers in Physiology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.115.05325"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2007.10.010"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(91)90003-l"},{"key":"12","first-page":"1455","article-title":"Carotid body enlargement in hypertension and other comorbidities evaluated by ultrasonography","volume":"37\/7","author":"T. Jie","year":"2019","journal-title":"Journal of Hypertension"},{"key":"13","first-page":"351","article-title":"Influence of age on position, shape and size of the carotid bodies in spontaneously hypertensive (SHR) and normotensive (NCR) rats","volume":"157","author":"J. O. Habeck","year":"1984","journal-title":"Anatomischer Anzeiger"},{"key":"14","first-page":"1021","article-title":"The carotid bodies of spontaneously hypertensive rats (SHR): a functional and morphologic study","volume":"40","author":"A. Honig","year":"1981","journal-title":"Acta Biologica et Medica Germanica"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2015.03.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.02.011"},{"key":"17","first-page":"356","article-title":"Role of the carotid body in the pathophysiology of heart failure","volume":"15\/4","author":"D. S. Harold","year":"2013","journal-title":"Current Hypertension Reports"},{"key":"18","first-page":"1","article-title":"Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure","volume":"5\/438","author":"J. M. Noah","year":"2014","journal-title":"Frontiers in Physiology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.21.6.a1268-c"},{"key":"20","first-page":"37","article-title":"The carotid bodies enlarge in some cases of cirrhosis of the liver","volume":"5\/1","author":"D. Heath","year":"1994","journal-title":"Cardioscience"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040102"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a2429"},{"key":"23","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00234-013-1273-3","article-title":"CT angiography in the detection of carotid body enlargement in patients with hypertension and heart failure","volume":"55","author":"N. Sreejit","year":"2013","journal-title":"Neuroradiology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2002001000002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.00064"},{"key":"26","first-page":"1","article-title":"Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease","volume":"5\/304","author":"S. F. Robert","year":"2014","journal-title":"Frontiers in Physiology"},{"key":"27","first-page":"2422","article-title":"Carotid chemoreceptor ablation improves survival in heart failure: rescuing autonomic control of cardiorespiratory function","volume":"62\/25","author":"D. R. Rodrigo","year":"2013","journal-title":"Journal of the American College of Cardiology"}],"container-title":["Radiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/rrp\/2021\/9499420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/rrp\/2021\/9499420.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/rrp\/2021\/9499420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T21:59:34Z","timestamp":1634335174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/rrp\/2021\/9499420\/"}},"subtitle":[],"editor":[{"given":"Lorenzo","family":"Faggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":27,"alternative-id":["9499420","9499420"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9499420","relation":{},"ISSN":["2090-195X","2090-1941"],"issn-type":[{"value":"2090-195X","type":"electronic"},{"value":"2090-1941","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}