{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:55:05Z","timestamp":1777956905855,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Clinical Key Discipline Construction Project Fund","award":["TJLCZDXKT005"],"award-info":[{"award-number":["TJLCZDXKT005"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To observe the clinical efficacy of periocular injection of triamcinolone acetonide (TA) and subpalpebral injection of botulinum toxin type A (BTXA) for the treatment of thyroid\u2010associated ophthalmopathy (TAO) with mild unilateral upper eyelid retraction. <jats:italic>Method<\/jats:italic>. This was a prospective randomized controlled study. A total of 68 cases of stable thyroid\u2010associated ophthalmopathy with mild upper eyelid retraction were collected at Hankou Aier Eye Hospital from Jan. 2015 to Dec. 2018 and randomly divided into two groups. Group A contained 33 patients who were administered TA by periocular injection once every 3 weeks for a total of 3 times. Group B contained 35 patients who were given a single subpalpebral administration of BTXA. The efficacy in the two groups was observed. <jats:italic>Results<\/jats:italic>. Compared with the two groups, the effective rate in both groups was 100% at 1 week and 1 month after treatment. The effective rate of Group A remained 100% at 3 months after treatment, and that of Group B decreased to 88.6%. At 1 week after treatment, the degree of correction in Group B was greater than that in Group A (<jats:italic>p<\/jats:italic> &lt; 0.001). At 1 month after treatment, it was not significantly different between the two groups (<jats:italic>p<\/jats:italic> &gt; &gt;&gt;0.05). At 3 months after treatment, it was less in Group B than in Group A (<jats:italic>p<\/jats:italic> &lt; 0.001). In Group A, there was one case of transient amaurosis, two cases of periorbital hemorrhage and swelling, and one mild case of sunken eyes. In Group B, four cases experienced recurrence after 3 months. <jats:italic>Conclusion<\/jats:italic>. Periocular injection of TA and subpalpebral injection of BTXA offer definite therapeutic efficacy for mild upper eyelid retraction associated with thyroid disease. The former has a long treatment period, large procedural risks, and stable efficacy. The latter is a simple procedure with a short treatment period but can easily recur.<\/jats:p>","DOI":"10.1155\/2021\/9514279","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T19:20:44Z","timestamp":1616181644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Observations on the Efficacy of Two Methods for the Treatment of Upper Eyelid Retraction in Thyroid\u2010Associated Ophthalmopathy"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-9929","authenticated-orcid":false,"given":"Dongping","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-4388","authenticated-orcid":false,"given":"Fengyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"286","article-title":"Diagnosis and treatment of upper eyelid retraction in thyroid-associated Ophthalmopathy","volume":"35","author":"Mou P.","year":"2017","journal-title":"Chinese Journal of Experimental Ophthalmology"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443828"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-7040.2017.09.013"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0412-4081.2017.08.004"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.18502\/jovr.v15i1.5948"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4845894"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.57701"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2016.01.007"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S266652"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1006-4443.2001.12.017"},{"key":"e_1_2_8_11_2","first-page":"44","article-title":"A Promising modified procedure for upper eyelid retraction-associated Graves\u2019 ophthalmopathy: transconjunctival lateral levator aponeurectomy","volume":"6","author":"Khatavi F.","year":"2017","journal-title":"Medical Hypothesis, Discovery and Innovation in Ophthalmology"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-017-1017-6"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2153-y"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2018.08.07"},{"key":"e_1_2_8_15_2","first-page":"68","article-title":"Clinical study of triamcinolone acetonide fornix subconjunctival injection in the treatment of upper eyelid withdrawal in thyroid-related ophthalmopathy","volume":"12","author":"Cao Y.","year":"2013","journal-title":"China Health Industry"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-2084.2016.05.059"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/IMCRJ.S177671"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12939"},{"key":"e_1_2_8_19_2","volume-title":"Comparision of the clinical efficacy on treatment of throid associated ophthalmopathy upper eyelid retraction with two medicines","author":"Zeng S. 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