{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:14:18Z","timestamp":1783656858654,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":340,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Ministry of Economy, Industry and Competitiveness of Spain","award":["RYC-2016-20471"],"award-info":[{"award-number":["RYC-2016-20471"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To investigate the potential predictive factors of the visual change achieved with accelerated epi\u2010on and epi\u2010off corneal collagen crosslinking (CXL) in keratoconus.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This retrospective comparative study analyzed 67 eyes treated with an accelerated epithelium\u2010on (epi\u2010on group) and epithelium\u2010off (epi\u2010off group) CXL. The clinical outcomes were evaluated and compared during a 1\u2010year follow\u2010up. Likewise, the relationship of the change achieved with both CXL techniques in the corrected distance visual acuity (CDVA) with different preoperative data was investigated.\n                    <jats:italic>Results<\/jats:italic>\n                    . The mean CDVA change at 3 months postoperatively was \u22120.04\u2009\u00b1\u20090.19 and \u22120.07\u2009\u00b1\u20090.25 in the epi\u2010on and epi\u2010off groups, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.809). In the epi\u2010on group, this change was significantly correlated with the preoperative apical (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.375,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045) and central corneal thickness (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.402,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031). In the epi\u2010off group, the CDVA change was significantly correlated with not only the preoperative apical (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.402,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028) and central corneal thickness (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.367,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046) but also with some topometric and aberrometric indices (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2264\u2009\u22120.374,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.042). Furthermore, the change in CDVA in the epi\u2010on group could be predicted from age, preoperative refractive astigmatism J\n                    <jats:sub>45<\/jats:sub>\n                    component, anterior corneal asphericity, and posterior corneal high order aberration root mean square (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.503). In the epi\u2010off group, the CDVA change could be predicted from the preoperative minimum corneal thickness and magnitude of the vertical anterior corneal primary coma component (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.446).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Clearly, different predictive factors of the visual change induced with the accelerated epi\u2010on and epi\u2010off CXL techniques are present, suggesting a different mechanism of action for stiffening the cornea and inducing changes in this structure.\n                  <\/jats:p>","DOI":"10.1155\/2021\/9680253","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T20:35:09Z","timestamp":1638909309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preliminary Characterization of Predictive Factors of the Visual Change after Epi\u2010On and Epi\u2010Off Corneal Collagen Crosslinking Techniques"],"prefix":"10.1155","volume":"2021","author":[{"given":"Sidi Mohamed","family":"Hamida Abdelkader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sebasti\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-4807","authenticated-orcid":false,"given":"David 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