{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:44:46Z","timestamp":1747190686669,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:p>Patients receiving complement inhibitor, eculizumab, are at high risk for infections with encapsulated organisms such as Neisseria due to impaired opsonophagocytic activity. Impaired complement immunity may increase the risk for dissemination of asymptomatic Neisseria gonorrhoeae. Disseminated Gonococcal Infection (DGI) is a rare but potentially life-threatening complication associated with eculizumab. Physicians should obtain adequate sexual histories from the patients and educate them on safe sexual practices. Here, we describe a case of DGI in a 32-year-old African American female patient with acetylcholine receptor antibody-positive (AChR+) generalized myasthenia gravis (gMG), receiving eculizumab.<\/jats:p>","DOI":"10.1155\/2021\/9713413","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T13:50:08Z","timestamp":1623678608000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse Gonococcal Infection (DGI) in a Patient with Treatment-Refractory Acetylcholine Receptor Antibody-Positive (AChR+) Generalized Myasthenia Gravis (gMG) Treated with Eculizumab"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-1707","authenticated-orcid":true,"given":"Nakul","family":"Katyal","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Missouri, Columbia, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latika","family":"Nirola","sequence":"additional","affiliation":[{"name":"Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naureen","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Critical Care Medicine, Staten Island University Hospital, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghav","family":"Govindarajan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri, Columbia, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-5890(96)00078-8"},{"article-title":"Drugs@FDA: soliris (BLA 125166)","year":"2018","author":"US Food and Drug Administration","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"journal-title":"Soliris (Eculizumab)","article-title":"Alexion Pharmaceuticals","year":"2018","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-781450"},{"volume-title":"Meningococcal ACIP Recommendations","year":"2017","author":"CDC","key":"6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3503"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6627e1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy958"},{"article-title":"Sexually transmitted diseases surveillance","year":"2018","author":"Centers for Disease Control and Prevention","key":"10"},{"key":"11","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"K. 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