{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:40:17Z","timestamp":1767890417231,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19441908000"],"award-info":[{"award-number":["19441908000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["81971590"],"award-info":[{"award-number":["81971590"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Scientific Foundation of China","award":["19441908000"],"award-info":[{"award-number":["19441908000"]}]},{"name":"Natural Scientific Foundation of China","award":["81971590"],"award-info":[{"award-number":["81971590"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2021,9,17]]},"abstract":"<jats:p>Objectives. The present study is aimed at investigating the frequency and associated factors of asymmetrical prominent veins (APV) in patients with acute ischemic stroke (AIS). Methods. Consecutive patients with AIS admitted to the Comprehensive Stroke Center of Shanghai Fourth People\u2019s Hospital between January 2013 and December 2017 were enrolled. MRI including diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), and susceptibility-weighted imaging (SWI) was performed within 12 hours of symptom onset. The volume of asymmetrical prominent veins (APV) was evaluated using the Signal Processing In nuclear magnetic resonance software (SPIN, Detroit, Michigan, USA). Multivariate analysis was used to assess relationships between APV findings and medical history, clinical variables as well as cardio-metabolic indices. Results. Seventy-six patients met the inclusion criteria. The frequency of <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>APV<\/a:mtext>\n                        <a:mo>\u2265<\/a:mo>\n                        <a:mn>10<\/a:mn>\n                        <a:mtext>\u2009<\/a:mtext>\n                        <a:mtext>mL<\/a:mtext>\n                     <\/a:math>\n                  <\/jats:inline-formula> was 46.05% (35\/76). Multivariate analyses showed that proximal artery stenosis or occlusion (\u226550%) (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>adjusted<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>odds<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mtext>ratio<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mfenced open=\"(\" close=\")\">\n                           <e:mrow>\n                              <e:mtext>OR<\/e:mtext>\n                           <\/e:mrow>\n                        <\/e:mfenced>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>660.0<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <i:mn>95<\/i:mn>\n                        <i:mi>%<\/i:mi>\n                        <i:mtext>CI<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>57.28<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>-7604.88) and history of atrial fibrillation (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <m:mtext>adjusted<\/m:mtext>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mtext>OR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>10.48<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <o:mn>95<\/o:mn>\n                        <o:mi>%<\/o:mi>\n                        <o:mtext>CI<\/o:mtext>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>1.78<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>-61.68) were independent factors associated with high APV (\u226510\u2009mL). Conclusion. Our findings suggest that the frequency of <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <q:mtext>APV<\/q:mtext>\n                        <q:mo>\u2265<\/q:mo>\n                        <q:mn>10<\/q:mn>\n                        <q:mtext>\u2009<\/q:mtext>\n                        <q:mtext>mL<\/q:mtext>\n                     <\/q:math>\n                  <\/jats:inline-formula> is high in patients with AIS within 12 hours of symptom onset. History of atrial fibrillation and severe proximal artery stenosis or occlusion are strong predictors of high APV as calculated by SPIN on the SWI map.<\/jats:p>","DOI":"10.1155\/2021\/9733926","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T19:05:18Z","timestamp":1631905518000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["The Frequency and Associated Factors of Asymmetrical Prominent Veins: A Predictor of Unfavorable Outcomes in Patients with Acute Ischemic Stroke"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurological Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 201619, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai, China"},{"name":"Translational Research Institute of Brain and Brain-Like Intelligence Affiliated to Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Administration Department of Nosocomial Infection Affiliated to Zhongshan Hospital of Dalian University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoshi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai, China"},{"name":"Translational Research Institute of Brain and Brain-Like Intelligence Affiliated to Tongji University School of Medicine, Shanghai, 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thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data","volume":"394","author":"B. 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