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If left untreated, periodontitis may lead to permanent tooth loss. Herein, we propose to design and improve a localized form of therapy comprising a chlorhexidine\u2010impregnated hydrogel. Hydrogel films were prepared by varying the ratio between cellulose (MCC) and carboxymethylcellulose sodium (CMC) using the crosslinker epichlorohydrin (ECH). The hydrogel was loaded with chlorhexidine. Increasing the CMC ratio led to a reduction in the number of pores, an increase in their size, lower glass transition temperature (<jats:italic>T<\/jats:italic><jats:sub><jats:italic>g<\/jats:italic><\/jats:sub>), decreased Young\u2019s modulus, and increased film stretching and affected the time of release. Bacterial and fungal zones of inhibition showed similar activity and were not affected by the CMC and MCC ratio. Hydrogels loaded with chlorhexidine prevented the growth of <jats:italic>S. oralis<\/jats:italic> and <jats:italic>C. albicans<\/jats:italic> microorganisms and may provide a promising local delivery system for treating periodontitis.<\/jats:p>","DOI":"10.1155\/2021\/9853977","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T21:20:23Z","timestamp":1631740823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Characterization of Chlorhexidine\u2010Impregnated Cellulose\u2010Based Hydrogel Films Intended for the Treatment of 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