{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:24:07Z","timestamp":1790886247397,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2018-87"],"award-info":[{"award-number":["2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of unknown etiology, which might be caused by oxidative stress and impaired antioxidant defense. <jats:italic>Objective<\/jats:italic>. To systematically investigate the markers of oxidative stress and antioxidant systems in the saliva and blood from OLP patients and healthy controls. <jats:italic>Methods<\/jats:italic>. The PubMed, Cochrane Library, and Embase were systematically queried to collect data from studies in which oxidative stress\/antioxidant markers from OLP and healthy subjects had been evaluated until March 10, 2021. <jats:italic>Results<\/jats:italic>. A total of 28 studies fulfilled inclusion criteria, and 25 of them, having 849 OLP patients and 1,052 control subjects and analyzing 12 oxidative stress and antioxidant state marker levels, were subjected to meta\u2010analysis. We found a significant decrease in total antioxidant capacity (TAC) and uric acid (UA) and a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels in the saliva and serum\/plasma of OLP patients. Moreover, a significant elevation of 8\u2010hydroxy\u2010deoxyguanosine (8\u2010OHdG) and advanced oxidation protein product (AOOP) level and a decrease in vitamin C were also observed in the saliva of the OLP group. In contrast, salivary vitamin A, zinc, glutathione peroxidase (GPx), vitamin E, and nitrite were not significantly different between the two groups. In single studies, markers of oxidative stresses such as superoxide dismutase (SOD) and 8\u2010isoprostanelevels were elevated in OLP, and antioxidant parameters such as glutathione (GSH) and total protein (TP) levels were dysregulated. <jats:italic>Conclusion<\/jats:italic>. This meta\u2010analysis helps to clarify the profile of oxidative stress and antioxidant state markers in OLP patients although existing evidence is rather heterogeneous and many studies are affected by several limitations. Larger and more standardized studies are warranted to ascertain whether these markers are potential causes or effects of OLP and whether antioxidant therapy improving oxidative stress will be useful.<\/jats:p>","DOI":"10.1155\/2021\/9914652","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T23:51:10Z","timestamp":1632786670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Systematic Review and Meta\u2010Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-3198","authenticated-orcid":false,"given":"Jia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-5625","authenticated-orcid":false,"given":"Yuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00662.x"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.04.004"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01441.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090010501"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117253"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010082"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/life11010060"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020723"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.795659"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5480267"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2346"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.47"},{"key":"e_1_2_10_14_2","article-title":"Oxidative stress in autism","volume":"10","author":"McGinnis W. R.","year":"2004","journal-title":"Alternative therapies in health and medicine"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365511003602455"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.5681\/joddd.2014.006"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.155902"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02221-9"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2018.vol32.0082"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssdds.2014.01.002"},{"key":"e_1_2_10_21_2","volume-title":"Cochrane Handbook for Systematic Reviews of Intervensions version 6.2 (updated February 2021)","author":"Higgins J. P.","year":"2021"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_10_24_2","unstructured":"RostomA. Dub\u00e9C. CranneyA. SaloojeeN. SyR. GarrittyC. SampsonM. ZhangL. YazdiF. MamaladzeV. andPanI. Celiac Disease. Rockville (MD): Agency for Healthcare Research and Quality (US); 2004 Sep. (Evidence Reports\/Technology Assessments No. 104.) Appendix D. Quality Assessment Forms http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK35156."},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060410"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12391"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520295.2015.1016115"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00955.x"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2014.50.2.58"},{"key":"e_1_2_10_32_2","first-page":"885","article-title":"Salivary oxidative status in patients with oral lichen planus","volume":"67","author":"Darczuk D.","year":"2016","journal-title":"Journal of physiology and pharmacology"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1506-4"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12153"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_19_17"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12522"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.119741"},{"key":"e_1_2_10_38_2","first-page":"710","article-title":"Estimation and comparison of levels of salivary nitric oxide in patients with oral lichen planus and controls","volume":"4","author":"Panjwani S.","year":"2013","journal-title":"International journal of preventive medicine"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.30476\/DENTJODS.2019.77842"},{"key":"e_1_2_10_40_2","first-page":"48","article-title":"Evaluation of serum nitric oxide level in patients with oral lichen planus","volume":"15","author":"Mehdipour M.","year":"2014","journal-title":"Journal of dentistry"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.29878"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5801570"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.16-0219"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.IJDR_289_19"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1159\/000452133"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21079"},{"key":"e_1_2_10_47_2","first-page":"52","article-title":"Evaluation of the serum zinc level in erosive and non-erosive oral lichen planus","volume":"15","author":"Gholizadeh N.","year":"2014","journal-title":"Journal of dentistry"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.7.2009"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300502.x"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01138.x"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290301x.x"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00751.x"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00096.x"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2010.08.007"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2018.19.5.1161"},{"key":"e_1_2_10_56_2","first-page":"3","article-title":"Oxidative stress in lichen planus","volume":"19","author":"Aly D. G.","year":"2010","journal-title":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.657"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.02.032"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.09.003"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705776"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652412800792598"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.10.018"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90301-R"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02053.x"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290602.x"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00394-4"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100004225004814"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5602_15"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1080\/15257770802257952"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12593"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70011-8"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.52.251"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.09.006"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.09.004"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1181-2"},{"key":"e_1_2_10_79_2","first-page":"327","article-title":"Immunomodulatory and potential therapeutic role of mesenchymal stem cells in periodontitis","volume":"65","author":"Racz G. Z.","year":"2014","journal-title":"Journal of physiology and pharmacology"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12837"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9914652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9914652.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/9914652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:56:00Z","timestamp":1723056960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9914652"}},"subtitle":[],"editor":[{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/9914652"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9914652","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9914652"}}