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However, the definite mechanism of aging-related inflammation in PD pathology needs further investigation. Our study is aimed at exploring the effect of inflamm-aging-related cytokines of interleukin-17 (IL-17) and interferon-\u03b3 (IFN-\u03b3) on osteoclastogenesis in vitro and periodontal destruction in vivo. For receptor activator of nuclear factor-\u03baB ligand- (RANKL-) primed bone marrow macrophages (BMMs), IL-17 and IFN-\u03b3 enhanced osteoclastogenesis, with the expression of osteoclastogenic mRNA (TRAP, c-Fos, MMP-9, Ctsk, and NFATc1) and protein (c-Fos and MMP-9) upregulated. Ligament-induced rat models were established to investigate the role of IL-17 and IFN-\u03b3 on experimental periodontitis. Both IL-17 and IFN-\u03b3 could enhance the local inflammation in gingival tissues. Although there might be an antagonistic interaction between IL-17 and IFN-\u03b3, IL-17 and IFN-\u03b3 could facilitate alveolar bone loss and osteoclast differentiation.<\/jats:p>","DOI":"10.1155\/2021\/9919024","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T20:20:14Z","timestamp":1628108414000},"page":"1-12","source":"Crossref","is-referenced-by-count":58,"title":["Inflamm-Aging-Related Cytokines of IL-17 and IFN-\u03b3 Accelerate Osteoclastogenesis and Periodontal Destruction"],"prefix":"10.1155","volume":"2021","author":[{"given":"Jingyi","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dai","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stomatology Department, Zhejiang Hospital, Hangzhou 310007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-1787","authenticated-orcid":true,"given":"Pei-Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-8844","authenticated-orcid":true,"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"issue":"48","key":"2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-0757.2008.00252.x","article-title":"Host response modulation in periodontics","volume":"2000","author":"P. 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