{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:49:00Z","timestamp":1787906940832,"version":"build-2784847793"},"reference-count":203,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-156017"],"award-info":[{"award-number":["PJT-156017"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN2016-05369"],"award-info":[{"award-number":["RGPIN2016-05369"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Cancer arises through a complex interplay between genetic, behavioral, metabolic, and environmental factors that combined trigger cellular changes that over time promote malignancy. In terms of cancer prevention, behavioral interventions such as diet can promote genetic programs that may facilitate tumor suppression; and one of the key tumor suppressors responsible for initiating such programs is p53. The p53 protein is activated by various cellular events such as DNA damage, hypoxia, heat shock, and overexpression of oncogenes. Due to its role in cell fate decisions after DNA damage, regulatory pathways controlled by p53 help to maintain genome stability and thus \u201cguard the genome\u201d against mutations that cause cancer. Dietary intake of flavonoids, a C<jats:sub>15<\/jats:sub> group of polyphenols, is known to inhibit cancer progression and assist DNA repair through p53\u2010mediated mechanisms in human cells via their antioxidant activities. For example, quercetin arrests human cervical cancer cell growth by blocking the G<jats:sub>2<\/jats:sub>\/M phase cell cycle and inducing mitochondrial apoptosis through a p53\u2010dependent mechanism. Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53\u2010mediated apoptosis. Finally, among vitamins, folic acid seems to play an important role in the chemoprevention of gastric carcinogenesis by enhancing gastric epithelial apoptosis in patients with premalignant lesions by significantly increased expression of p53. In this review, we discuss the role of these and other dietary antioxidants in p53\u2010mediated cell signaling in relation to cancer chemoprevention and tumor suppression in normal and cancer cells.<\/jats:p>","DOI":"10.1155\/2021\/9924328","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T21:06:14Z","timestamp":1624914374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Role of Dietary Antioxidants in p53\u2010Mediated Cancer Chemoprevention and Tumor Suppression"],"prefix":"10.1155","volume":"2021","author":[{"given":"J. P. Jose","family":"Merlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-0052","authenticated-orcid":false,"given":"H. P. Vasantha","family":"Rupasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3466-6316","authenticated-orcid":false,"given":"Graham","family":"Dellaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.152915"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5367014"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110254"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21397"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-13-S2-S14"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109004"},{"key":"e_1_2_14_9_2","first-page":"55","article-title":"Natural antioxidants: a review on therapeutic applications","volume":"4","author":"Jaydeokar A.","year":"2012","journal-title":"Research Journal of Pharmacology and Pharmacodynamics"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2020.104631"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.111"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190914496"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000119"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.01.038"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400866"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.03.022"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.08.005"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2014.19.1.14"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.04.007"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904280106"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.05.017"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33948-6"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2018.02.006"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.018"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90045-7"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.099"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2018.05.007"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.7.11194"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb866"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00739"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.434"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5387.290"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.155"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5468.1053"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2008.10817532"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00381-2"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132241599"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.1.1"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100281"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.640"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9211-0_18"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.03.007"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104130200"},{"key":"e_1_2_14_44_2","first-page":"6304","article-title":"Participation of p53 protein in the cellular response to DNA damage","volume":"51","author":"Kastan M. B.","year":"1991","journal-title":"Cancer Research"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009528200"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.10.3705-3714.2000"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1667\/rr13572.1"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01639-13"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2018.11.008"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg186"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.4.914"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.10.006"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.011"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.036"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.06.001"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjx001"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07676.x"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00504.x"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113206660325"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012414-040349"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.15.1739"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.07.002"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2017.08.001"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.050"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-230x(08)60785-x"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601010"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.294"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.05.008"},{"key":"e_1_2_14_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.03.002"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.010"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1063-9"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(04)00036-4"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.11.005"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.151"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00012"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3010994"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc864"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4007"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/342749a0"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2274789"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3380"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1368-y"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0705-7"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.011"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0534"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.71"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0246-9"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.7.3735"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00696-5"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207553"},{"key":"e_1_2_14_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00073-8"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2952"},{"key":"e_1_2_14_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206708"},{"key":"e_1_2_14_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380888-2.00003-0"},{"key":"e_1_2_14_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.10.013"},{"key":"e_1_2_14_96_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.914401"},{"key":"e_1_2_14_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00110-7"},{"key":"e_1_2_14_98_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108297"},{"key":"e_1_2_14_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.026"},{"key":"e_1_2_14_100_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061131"},{"key":"e_1_2_14_101_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1200304"},{"key":"e_1_2_14_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601209"},{"key":"e_1_2_14_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.09.007"},{"key":"e_1_2_14_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb945"},{"key":"e_1_2_14_105_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.3.289"},{"key":"e_1_2_14_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600812"},{"key":"e_1_2_14_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2514"},{"key":"e_1_2_14_108_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.8.4180"},{"key":"e_1_2_14_109_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1301205"},{"key":"e_1_2_14_110_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083430"},{"key":"e_1_2_14_111_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1547007"},{"key":"e_1_2_14_112_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9050041"},{"key":"e_1_2_14_113_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.842500"},{"key":"e_1_2_14_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.01.001"},{"key":"e_1_2_14_115_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-3-9"},{"key":"e_1_2_14_116_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7010030"},{"key":"e_1_2_14_117_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8080286"},{"key":"e_1_2_14_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13792"},{"key":"e_1_2_14_119_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.2.152"},{"key":"e_1_2_14_120_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-08-0689"},{"key":"e_1_2_14_121_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590459"},{"key":"e_1_2_14_122_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000950"},{"key":"e_1_2_14_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.02.008"},{"key":"e_1_2_14_124_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1853"},{"key":"e_1_2_14_125_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200578200"},{"key":"e_1_2_14_126_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.1202"},{"key":"e_1_2_14_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.025"},{"key":"e_1_2_14_128_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212574200"},{"key":"e_1_2_14_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80521-8"},{"key":"e_1_2_14_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114407"},{"key":"e_1_2_14_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0016-0"},{"key":"e_1_2_14_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_14_133_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238991"},{"key":"e_1_2_14_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.028"},{"key":"e_1_2_14_135_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom8020014"},{"key":"e_1_2_14_136_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4149"},{"key":"e_1_2_14_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.02.007"},{"key":"e_1_2_14_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.037"},{"key":"e_1_2_14_139_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24128"},{"key":"e_1_2_14_140_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5706"},{"key":"e_1_2_14_141_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.14.4503"},{"key":"e_1_2_14_142_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092734"},{"key":"e_1_2_14_143_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5196"},{"key":"e_1_2_14_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26190"},{"key":"e_1_2_14_145_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507611200"},{"key":"e_1_2_14_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.11.023"},{"key":"e_1_2_14_147_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.22778"},{"key":"e_1_2_14_148_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.217"},{"key":"e_1_2_14_149_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070728"},{"key":"e_1_2_14_150_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092624"},{"key":"e_1_2_14_151_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7864269"},{"key":"e_1_2_14_152_2","doi-asserted-by":"publisher","DOI":"10.3233\/JBR-180305"},{"key":"e_1_2_14_153_2","first-page":"289","article-title":"Ascorbic acid induces apoptosis in adult T-cell leukemia","volume":"27","author":"Harakeh S.","year":"2007","journal-title":"Anticancer Research"},{"key":"e_1_2_14_154_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3073"},{"key":"e_1_2_14_155_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12951"},{"key":"e_1_2_14_156_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i11.1571"},{"key":"e_1_2_14_157_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-43"},{"key":"e_1_2_14_158_2","first-page":"2710","article-title":"Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression","volume":"20","author":"Diao Q. X.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_14_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2013.07.001"},{"key":"e_1_2_14_160_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh142"},{"key":"e_1_2_14_161_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8080286"},{"key":"e_1_2_14_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2003.10.014"},{"key":"e_1_2_14_163_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.609"},{"key":"e_1_2_14_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.020"},{"key":"e_1_2_14_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.07.007"},{"key":"e_1_2_14_166_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3420"},{"key":"e_1_2_14_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00233-5"},{"key":"e_1_2_14_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.09.015"},{"key":"e_1_2_14_169_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12229"},{"key":"e_1_2_14_170_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020447"},{"key":"e_1_2_14_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.04.009"},{"key":"e_1_2_14_172_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1767198"},{"key":"e_1_2_14_173_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b01002"},{"key":"e_1_2_14_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(10)60092-7"},{"key":"e_1_2_14_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.07.014"},{"key":"e_1_2_14_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00323-1"},{"key":"e_1_2_14_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101320"},{"key":"e_1_2_14_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.12.001"},{"key":"e_1_2_14_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(00)00101-0"},{"key":"e_1_2_14_180_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900629"},{"key":"e_1_2_14_181_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10034"},{"key":"e_1_2_14_182_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-14-6"},{"key":"e_1_2_14_183_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10136-009-0031-7"},{"key":"e_1_2_14_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.08.012"},{"key":"e_1_2_14_185_2","first-page":"34","article-title":"The role of harmine in up-regulating p53 gene expression and inducing apoptosis in MCF-7 cell line","volume":"11","author":"Roshankhah S.","year":"2020","journal-title":"Middle East Journal of Cancer"},{"key":"e_1_2_14_186_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20194065"},{"key":"e_1_2_14_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.02.005"},{"key":"e_1_2_14_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102153"},{"key":"e_1_2_14_189_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12519"},{"key":"e_1_2_14_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdc.2018.01.005"},{"key":"e_1_2_14_191_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1345853"},{"key":"e_1_2_14_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.10.041"},{"key":"e_1_2_14_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.06.010"},{"key":"e_1_2_14_194_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180403145137"},{"key":"e_1_2_14_195_2","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_14_196_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300547200"},{"key":"e_1_2_14_197_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204746"},{"key":"e_1_2_14_198_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9100973"},{"key":"e_1_2_14_199_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i16.1679"},{"key":"e_1_2_14_200_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-013-9641-1"},{"key":"e_1_2_14_201_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-0808-y"},{"key":"e_1_2_14_202_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023395"},{"key":"e_1_2_14_203_2","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.10286"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9924328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/9924328.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/9924328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:30:17Z","timestamp":1723055417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9924328"}},"subtitle":[],"editor":[{"given":"German","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":203,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/9924328"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9924328","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9924328"}}