{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:51:36Z","timestamp":1769122296054,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To study the protective effect of trimetazidine on myocardial cells in rats with myocardial infarction and explore its effect on ERK signaling pathway. <jats:italic>Methods<\/jats:italic>. 40 SD rats were randomly divided into the sham operation group, model group, low\u2010dose group, and high\u2010dose group (intra\u2010abdominal injection of trimetazidine 5\u2009mg\/kg and 10\u2009mg\/kg, respectively), construction of rat myocardial infarction model by coronary artery left anterior descending artery ligation. 7 days after surgery, the survival rate and cardiac function of each group of rats were recorded. The myocardial infarct size was detected by TTC staining. The apoptosis level of rat cardiomyocytes was detected by TUNEL staining. The content of ROS in rat cardiomyocytes was detected by DCFH\u2010DA. Western\u2010blot was used to detection of Caspase\u20103, Bcl\u20102\/Bax, and ERK signaling pathway\u2010related proteins in myocardial tissue. <jats:italic>Results<\/jats:italic>. Compared with the model group, the survival rate of the rats in the low\u2010dose group and the high\u2010dose group was significantly increased (<jats:italic>P<\/jats:italic> &lt; 0.01), the cardiac function was significantly improved (<jats:italic>P<\/jats:italic> &lt; 0.01), the myocardial infarct size was significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.01), the level of apoptosis was significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.01), the content of ROS in cardiomyocytes was significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.01), the protein expression of Caspase\u20103 and NF\u2010<jats:italic>\u03ba<\/jats:italic>B in cardiomyocytes was significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.01), and the expression of Bcl\u20102\/Bax and p\u2010ERK were significantly increased (<jats:italic>P<\/jats:italic> &lt; 0.01). <jats:italic>Conclusion<\/jats:italic>. Trimetazidine can activate ERK signaling pathway in cardiomyocytes of rats with myocardial infarction, increase the expression of p\u2010ERK, decrease the content of ROS in cardiomyocytes, decrease the expression of apoptotic proteins, reduce myocardial infarct size, improve cardiac function, and increase myocardial function.<\/jats:p>","DOI":"10.1155\/2021\/9924549","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T08:42:23Z","timestamp":1633509743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["[Retracted] Protective Mechanism of Trimetazidine in Myocardial Cells in Myocardial Infarction Rats through ERK Signaling Pathway"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-7134","authenticated-orcid":false,"given":"Zhenjun","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/17482940701744334"},{"key":"e_1_2_10_2_2","first-page":"3451","article-title":"Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb","volume":"8","author":"Fan Z.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017662"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2018.72335"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.06.007"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7730"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7705"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.10.143"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.10.007"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.08.006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.09.016"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2328"},{"key":"e_1_2_10_13_2","first-page":"672","article-title":"Leukemic bone marrow stromal cells in vitro protect leukemic cell line Jurkat cells from daunorubicin-induced apoptosis","volume":"24","author":"Li Z. 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