{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:01:40Z","timestamp":1777298500821,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["2019KY735"],"award-info":[{"award-number":["2019KY735"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Lipid levels become decreased in cirrhotic patients and are correlated with disease severity. In the present study, we investigated the impact of serum high\u2010density lipoprotein cholesterol (HDL\u2010C) on prognosis in patients with HBV\u2010associated decompensated cirrhosis (HBV\u2010DeCi). <jats:italic>Methods<\/jats:italic>. The medical records of 153 HBV\u2010DeCi patients were analyzed. Patients were separated into survivors and nonsurvivors according to their 30\u2010day survival. Univariate and multivariate analyses were performed to identify predictors of poor outcomes, and the performance of these predictors was evaluated by receiver operating characteristic (ROC) curve analysis. <jats:italic>Results<\/jats:italic>. The 30\u2010day mortality in the cohort was 18.9%. HDL\u2010C levels differed markedly between survivors and nonsurvivors. On multivariate analysis, Model for End\u2010stage Liver Disease (MELD) score and HDL\u2010C level were identified as independent risk factors for mortality in HBV\u2010DeCi patients. In the ROC analyses, the prognostic accuracy for mortality was similar between HDL\u2010C (area under ROC curve: 0.785) and MELD score (area under ROC curve: 0.853). <jats:italic>Conclusions<\/jats:italic>. Low HDL\u2010C level had a significant correlation with mortality in HBV\u2010DeCi patients and can be used as a simple marker for risk assessment and selection of therapeutic options.<\/jats:p>","DOI":"10.1155\/2021\/9927330","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T23:35:06Z","timestamp":1627428906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of Low High\u2010Density Lipoprotein Cholesterol Levels with Poor Outcomes in Hepatitis B\u2010Associated Decompensated Cirrhosis Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-0660","authenticated-orcid":false,"given":"Xia","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-5369","authenticated-orcid":false,"given":"XiaoYun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-8444","authenticated-orcid":false,"given":"SongQing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-7835","authenticated-orcid":false,"given":"Zhong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9202-826X","authenticated-orcid":false,"given":"Jianjiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-6946","authenticated-orcid":false,"given":"Ming","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_10_2_2","first-page":"2157","article-title":"Natural history of liver cirrhosis in south China based on a large cohort study in one center: a follow-up study for up to 5 years in 920 patients","volume":"125","author":"Wang S. 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