{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:49:01Z","timestamp":1792291741796,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2021,7,19]]},"abstract":"<jats:p>The standard serologic markers used to diagnose hepatitis B infection include hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), total hepatitis B core antibody (anti-HBc), and IgM antibody to hepatitis B core antigen (IgM anti-HBc). Different markers or combinations of markers are used to identify different phases of HBV infection and determine whether a patient has acute or chronic infection or immunity due to prior infection or vaccination or is seronegative and susceptible to future infection. Isolated HBsAg seropositivity is a peculiar serological pattern that requires investigation. Herein, we present a case of an asymptomatic female without a history of liver disease or evident risk factors for hepatitis, who underwent screening for infectious disease prior to resection of basal cell carcinoma involving her eyelid. The patient\u2019s laboratory testing showed positivity for HBsAg and the HIV 1\/2 screen. To investigate, we performed serial dilutions, utilized heterophilicantibody blocking tubes, and repeated analysis using a different commercial assay (Abbott Architect i2000), all in support of a false-positive result attributed to a heterophilic antibody. Hence, we demonstrate that heterophilic antibody interference can result in isolated HBsAg positivity and recommend considering this form of interference in the differential where there is low clinical suspicion for viral infection.<\/jats:p>","DOI":"10.1155\/2021\/9928098","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T02:20:05Z","timestamp":1626747605000},"page":"1-3","source":"Crossref","is-referenced-by-count":6,"title":["An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-0513","authenticated-orcid":true,"given":"Victoria","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-5982","authenticated-orcid":true,"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-6682","authenticated-orcid":true,"given":"Sabrina E.","family":"Racine-Brzostek","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-3082","authenticated-orcid":true,"given":"Gadi","family":"Lalazar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-992X","authenticated-orcid":true,"given":"He S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0160-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28503"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.294157"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1993.tb01672.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12675"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.09.030"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.040501"},{"issue":"2","key":"8","first-page":"105","article-title":"Interference in immunoassay","volume":"25","author":"J. Tate","year":"2004","journal-title":"Clinical Biochemistry Review"},{"key":"9","article-title":"Quick reference guide: recommended laboratory HIV testing algorithm for serum or plasma specimens","author":"Centers for Disease Control and Prevention","year":"2018"},{"key":"10","volume-title":"Monospot Test","author":"N. Stuempfig","year":"2019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev088.001"}],"container-title":["Case Reports in Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2021\/9928098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2021\/9928098.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2021\/9928098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T02:20:11Z","timestamp":1626747611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihep\/2021\/9928098\/"}},"subtitle":[],"editor":[{"given":"Haruki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":11,"alternative-id":["9928098","9928098"],"URL":"https:\/\/doi.org\/10.1155\/2021\/9928098","relation":{},"ISSN":["2090-6595","2090-6587"],"issn-type":[{"value":"2090-6595","type":"electronic"},{"value":"2090-6587","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,19]]}}}