{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:13:40Z","timestamp":1767093220873,"version":"3.37.3"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"],"award-info":[{"award-number":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Project","award":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"],"award-info":[{"award-number":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"]}]},{"name":"Key Research and Development Program of Shaanxi","award":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"],"award-info":[{"award-number":["81873173","81974584","2019YFC1708703","2019ZDLSF04-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,29]]},"abstract":"<jats:p>Objective. To systematically evaluate the efficacy and safety of XFZYD for coronary heart disease (CHD). Methods. A comprehensive literature search of randomized controlled trials using XFZYD for CHD was conducted in 10 electronic databases from their establishment to December 20, 2020. The researchers screened the relevant trials in NoteExpress, extracted the data in duplicate independently, assessed the risk of bias in the trials using the Cochrane collaboration tool, and then used Rev Man 5.3 for data analysis. Results. 30 trials with 3126 participants were included for meta-analysis. The results showed that the clinical effects of XFZYD and its combination with chemical drugs (CD) were 1.13 (RR; 1.13; 95% CI, 1.03 to 1.24) and 1.26 (RR; 1.26; 95% CI, 1.20 to 1.32) times those of CD, respectively. And, it could also improve electrocardiogram effect, which was 1.63 (RR; 1.63; 95% CI, 1.04 to 2.53) times that of CD. XFZYD could not only decrease duration of angina pectoris and improve vascular endothelial function but also obviously reduce the TCM syndrome score. When used in combination with CD, it could also lower AF, correct the dyslipidemia, and reduce the blood viscosity. Conclusion. These results demonstrated that XFZYD had great advantages in treating CHD with no obvious adverse reactions. Therefore, it is believed that XFZYD is more suitable for CHD patients with clinical indicators of dyslipidemia, high blood viscosity, or vascular endothelial dysfunction. This study is the first systematic review and meta-analysis with some unique ways, including its comprehensiveness, large-scale search, the novelty of findings, and transparent approach.<\/jats:p>","DOI":"10.1155\/2021\/9931826","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T20:04:13Z","timestamp":1632945853000},"page":"1-19","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and Safety of Xue-Fu-Zhu-Yu Decoction for Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-1722","authenticated-orcid":true,"given":"Shuo","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine (Guang\u2019anmen Hospital), Beijing University of Chinese Medicine, Beijing, China"},{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-4128","authenticated-orcid":true,"given":"Zhen-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"International Programs Office, Shaanxi University of Chinese Medicine, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-057X","authenticated-orcid":true,"given":"Yu-Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-1781","authenticated-orcid":true,"given":"Jin-Long","family":"Duan","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-7651","authenticated-orcid":true,"given":"Kui-Wu","family":"Yao","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"7","key":"1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.5551\/jat.51961","article-title":"Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community","volume":"27","author":"H. 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